B6-hEGFR
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
B6-hEGFR
Product ID
C001782
Gene Name
Background
C57BL/6NCya
Gene Alias
Wa5; wa2; Erbb; Errp; wa-2; Errb1; 9030024J15Rik
Classification
Tumor Target Humanized Models,Full-Gene Humanized Models
NCBI ID
Phenotype
Chromosome
11
Document
Note: When using this mouse strain in a publication, please cite “B6-hEGFR mice (Catalog C001782) were purchased from Cyagen.”
Strain Description
The B6-hEGFR mouse is a humanized model constructed by replacing exon 2 and part of intron 2 of the mouse Egfr gene with the EGFR Chimeric cDNA-WPRE BGH pA cassette. The murine signal peptide and partial extracellular domain (c.1~88) are preserved. B6-hEGFR mice can be used for research into the pathogenesis of various cancers, including non-small cell lung cancer (adenocarcinoma), glioblastoma, colorectal cancer, and breast cancer, as well as for the screening, development, and safety assessment of EGFR-targeted therapies.
Application Area
EGFR-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of various cancers, including non-small cell lung cancer (adenocarcinoma), glioblastoma, colorectal cancer, and breast cancer
Validation Data