B6-hTSLP
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Model Name
B6-hTSLP
Product ID
C001809
Gene Name
Background
C57BL/6NCya
Gene Alias
--
Classification
Immune Target Humanized Models,Cytokine Humanized Models,Full-Gene Humanized Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
5
Document
Note: When using this mouse strain in a publication, please cite “B6-hTSLP mice (Catalog C001809) were purchased from Cyagen.”
Strain Description
The B6-hTSLP mouse is a humanized model constructed using gene editing technology, where the mouse Tslp endogenous domain (aa.20~140) was replaced with the human TSLP domain (aa.29~159). The murine signal peptide (aa.1~19) was preserved. This model can be used for studying the pathological mechanisms and therapeutic approaches of allergic and inflammatory diseases and for the development of TSLP-targeted drugs.
Application Area
TSLP-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of allergic and inflammatory diseases
Validation Data