B6-huIL4/huIL13/huTSLP Mouse
Product Name
B6-huIL4/huIL13/huTSLP Mouse
Product ID
C001812
Strain Name
C57BL/6NCya-Il4em1(hIL4)Il13em1(hIL13)Tslpem1(hTSLP)/Cya
Backgroud
C57BL/6NCya
Status
When using this mouse strain in a publication, please cite “B6-huIL4/huIL13/huTSLP Mouse (Catalog C001812) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Gene Alias
BSF1, IL-4, BCGF1, BSF-1, BCGF-1, P600, IL-13
Chromosome
Chr 5, Chr 5, Chr 5
MGI ID
Datasheet
Strain Description
The B6-huIL4/huIL13/huTSLP mouse is a triple-gene humanized model obtained by mating B6-huIL4 mice (catalog number: C001628), B6-huIL13 mice (catalog number: C001634), and B6-huTSLP mice (catalog number: C001809). This model can be used for the mechanism research and development of treatment methods in allergic diseases, inflammation and autoimmune diseases, Th2 immune response, parasitic infections, tumor immunology, as well as the development of IL-4/IL13/TSLP-targeted drugs, and the pre-clinical evaluation of drug efficacy and safety.
Strain Strategy
Figure 1. Gene editing strategy of B6-huIL4 mice. The sequences from the ATG start codon to the TAG stop codon of the endogenous mouse Il4 gene are replaced with the sequences from the ATG start codon to the TGA stop codon of the human IL4 gene.
Figure 2. Gene editing strategy of B6-huIL13 mice. The sequences from the ATG start codon to the TAA stop codon of the endogenous mouse Il13 gene were replaced with the sequences from the ATG start codon to the TGA stop codon of the human IL13 gene.
Figure 3. Gene editing strategy of B6-huTSLP mice. The mouse Tslp endogenous domain was replaced with the human TSLP domain. The murine signal peptide was preserved.
Application Area
Screening, development, and pre-clinical evaluation of IL-4/IL13/TSLP-targeted drugs;
Research on allergic diseases, inflammation, and autoimmune diseases;
Research on immune regulation, Th2 response, parasitic infections, and tumor immunity.
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.