Tmem119-CreERT2
Product ID:
C001826
Background:
C57BL/6JCya
Documents:
Expressing Tissues/Cells:
Microglia
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Basic Information
Model Name
Tmem119-CreERT2
Product ID
C001826
Gene Name
Background
C57BL/6JCya
Gene Alias
obif
Classification
Cre Driver Lines
NCBI ID
Phenotype
Chromosome
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Document
Note: When using this mouse strain in a publication, please cite “Tmem119-CreERT2 mice (Catalog C001826) were purchased from Cyagen.”
Strain Description
The Tmem119-CreERT2 mouse is generated via gene-editing technology by integrating a tamoxifen-inducible CreERT2 recombinase cassette into the stop codon of the murine Tmem119 gene, thereby driving its specific expression. This construction strategy ensures that the expression pattern of CreERT2 recombinase mimics that of the endogenous murine Tmem119 gene. Before tamoxifen induction, CreERT2 is confined to the cytoplasm; only after tamoxifen treatment can CreERT2 recombinase translocate into the nucleus to exert its genetic recombination function. When this strain is crossed with mice containing loxP sites, tamoxifen induction triggers Cre-mediated sequence recombination between loxP sites specifically in microglia. Tmem119-CreERT2 mice are applicable for researching the functions of resident microglia in the central nervous system, as well as bone development, osteoblast differentiation, and osteosarcoma.
Validation Data