Myh6-MerCreMer
Product ID:
C001831
Background:
C57BL/6JCya
Documents:
Expressing Tissues/Cells:
Cardiomyocytes
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
Myh6-MerCreMer
Product ID
C001831
Gene Name
Background
C57BL/6JCya
Gene Alias
Myhca; Myhc-a; alphaMHC; alpha-MHC; A830009F23Rik
Classification
Cre Driver Lines
NCBI ID
Phenotype
Chromosome
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Document
Note: When using this mouse strain in a publication, please cite “Myh6-MerCreMer mice (Catalog C001831) were purchased from Cyagen.”
Strain Description
Myh6-MerCreMer mice were generated by inserting a Tamoxifen-inducible Cre recombinase protein MerCreMer gene expression element controlled by the mouse Myh6 promoter into the mouse H11 safe harbor site. Before induction, MerCreMer is only present in the cytoplasm and can only enter the nucleus to exert its recombination effect after Tamoxifen treatment. When bred with mice containing a loxP site-flanked sequence, Cre recombinase-mediated deletion of the flanked sequence will occur in the cardiomyocytes of the offspring after Tamoxifen induction. Compared with the Myh6-CreEsr1 mouse strain (Catalog No.: C001443), this strain shows improved survival outcomes in mice after tamoxifen induction.
Validation Data