B6-hROR1
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Basic Information
Model Name
B6-hROR1
Product ID
C001848
Gene Name
Background
C57BL/6NCya
Gene Alias
NTRKR1; dJ537F10.1
Classification
Tumor Target Humanized Models
NCBI ID
Phenotype
Chromosome
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Note: When using this mouse strain in a publication, please cite “B6-hROR1 mice (Catalog C001848) were purchased from Cyagen.”
Strain Description
B6-hROR1 mouse is a humanized model constructed by replacing exon 2 and partial intron 2 of the mouse Ror1 gene with the ROR1 chimeric CDS of exon 2~9-3'UTR of mouse Ror1-WPRE-BGH pA expression cassette. The murine signal peptide (aa.1~29) of Ror1 was preserved. This model is applicable to research on tumor biology and pathological mechanisms, tumor immunotherapy studies, as well as the screening, development, and safety evaluation of ROR1-targeted drugs.
Application Area
Screening, development, and preclinical evaluation of ROR1-targeted drugs, such as CAR-T cell therapies, antibody-drug conjugates (ADCs), and monoclonal/bispecific antibodies
Research on tumor biology and pathological mechanisms
Research on tumor immunotherapies
Validation Data