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B6-hCD3/hCD19
Product ID:
C001851
Background:
C57BL/6NCya
Documents:
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Basic Information
Model Name
B6-hCD3/hCD19
Product ID
C001851
Gene Name
CD3E, CD3D, CD3G, CD19
Background
C57BL/6NCya
Gene Alias
T3E; TCRE; IMD18; CD3epsilon; T3D; IMD19; CD3DELTA; CD3-DELTA; T3G; IMD17; CD3GAMMA; CD3-GAMMA; B4; CVID3
Classification
Immune Target Humanized Models,Autoimmune Disease Models
NCBI ID
916, 915, 917, 930
Phenotype
MGI:88332, MGI:88331, MGI:88333, MGI:88319
Chromosome
--
More
Rare Disease Data Center >>
Document
Click here to download >>
Note
Note: When using this mouse strain in a publication, please cite “B6-hCD3/hCD19 mice (Catalog C001851) were purchased from Cyagen.”
Strain Description
B6-hCD3/hCD19 mouse is a dual-gene humanized model generated by crossing B6-hCD3 mice (Catalog No.: C001325) with B6-hCD19 mice (Catalog No.: C001731). This strain is applicable for the development, validation, and preclinical evaluation of bispecific antibodies targeting human CD3/CD19, as well as for research on malignant tumors such as B-cell lymphoma and immunosuppressive therapies for autoimmune diseases. It serves as an ideal platform for the development of combination therapies.
Application Area
Area
Research on T cell activation and antigen recognition
Area
Research on B cell development and function
Area
Research on immunosuppressive therapies for autoimmune diseases
Area
Research on the mechanisms and therapeutic approaches of malignant tumors such as B-cell lymphoma
Area
Screening, development, and preclinical evaluation of human CD3/CD19-targeted drugs
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