G129 (Ifngr1 KO)
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Basic Information
Model Name
G129 (Ifngr1 KO)
Product ID
C001892
Gene Name
Background
129S2/SvPasCya
Gene Alias
Ifgr; CD119; Ifngr; Nktar; IFN-gammaR
Classification
Immunodeficient Mouse Models,Infectious Disease Models
NCBI ID
Phenotype
Chromosome
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Datasheet
Note: When using this mouse strain in a publication, please cite “G129 (Ifngr1 KO) mice (Catalog C001892) were purchased from Cyagen.”
Strain Description
The G129 (Ifngr1 KO) mice on a 129 background are a type II (γ) interferon receptor (Ifngr1) gene knockout model. The absence of the IFNGR1 protein in these mice results in defective gamma interferon receptor function, which reduces natural resistance and may increase susceptibility to certain viral infections. Homozygous G129 (Ifngr1 KO) mice are viable and fertile.
Application Area
Investigating the pathogenesis and developing vaccines for arboviruses such as DENV, ZIKV, YFV, and CHIKV
Studying antiviral immune responses, interferon stimulation, and JAK-STAT signaling
Validation Data