Prom1-KO Mouse
Product Name
Prom1-KO Mouse
Product ID
C001973
Strain Name
C57BL/6JCya-Prom1em1/Cya
Backgroud
C57BL/6JCya
Status
When using this mouse strain in a publication, please cite “Prom1-KO Mouse (Catalog C001973) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Gene Name
Prom1
Gene Alias
Prom, AC133, CD133, Prom-1, Proml1, 4932416E19Rik
NCBI ID
Chromosome
Chr 5 (Mouse)
MGI ID
Datasheet
Strain Description
The PROM1 gene (Prominin-1) encodes a pentaspan transmembrane glycoprotein known as CD133, which is characterized by its unique structure of five transmembrane domains and two large extracellular loops [1]. Primarily expressed in neuroepithelial and epithelial cells, as well as various stem and progenitor cells, the encoded protein localizes specifically to membrane protrusions such as microvilli, cilia, and filopodia, where it plays a critical role in maintaining plasma membrane organization and regulating cellular polarity. Beyond its function as a universal marker for hematopoietic and cancer stem cells, PROM1 is vital for the proper morphogenesis of photoreceptor cells in the retina [2]. Consequently, mutations in this gene are most notably associated with inherited retinal degenerations, including Stargardt disease 4, retinitis pigmentosa 41, and various forms of macular dystrophy, highlighting its essential role in visual health and structural integrity at the cellular level [3].
Prom1-KO mice are a gene knockout (KO) model in which exons 2-20 of the Prom1 gene in mice have been knocked out using gene-editing technology. This model can be used for studying the pathogenic mechanisms of Stargardt disease (STGD), retinitis pigmentosa (RP), and various forms of macular dystrophy, as well as for the development of relevant treatment methods.
Reference
Glumac PM, LeBeau AM. The role of CD133 in cancer: a concise review. Clin Transl Med. 2018 Jul 9;7(1):18.
Yanardag S, Rhodes S, Saravanan T, Guan T, Ramamurthy V. Prominin 1 is crucial for the early development of photoreceptor outer segments. Sci Rep. 2024 May 7;14(1):10498.
D'Esposito F, Gagliano C, Vallone S, Cappellani F, Gagliano G, Randazzo V, Tognetto D, Esposito G, Zeppieri M. Clinical and Molecular Findings in PROM1-Associated Inherited Retinal Dystrophies. Genes (Basel). 2025 Nov 1;16(11):1299.
Strain Strategy
The mouse Prom1 gene contains 22 exons. The ATG start codon is located in exon 1, and the TGA stop codon is located in exon 22. In this strain, the region of exon 2-20 has been knocked out using gene editing technology.
Figure 1. Gene editing strategy of Prom1-KO mice.
Application Area
Research on the Stargardt disease (STGD);
Research on retinitis pigmentosa (RP);
Research on the various macular dystrophies.
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