huTSLP/hTSLPR Mouse
Product Name
huTSLP/hTSLPR Mouse
Product ID
C001991
Strain Name
C57BL/6NCya-Tslpem1(hTSLP)Crlf2tm1(hCRLF2)/Cya
Backgroud
C57BL/6NCya
Status
When using this mouse strain in a publication, please cite “huTSLP/hTSLPR Mouse (Catalog C001991) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Gene Alias
CRL2, TSLPR, CRLF2Y
Chromosome
Chr X, Chr 5
MGI ID
Datasheet
Strain Description
The huTSLP/hTSLPR mice are a dual-gene humanized model obtained by mating huTSLP mice (catalog No.: C001809) with hTSLPR mice (catalog No.: C001942). This model can be used for the mechanism research and treatment development of allergic diseases, inflammation, and autoimmune diseases, as well as the development of TSLP/TSLPR-targeted drugs.
Strain Strategy
The huTSLP/hTSLPR mice are a dual-gene humanized model obtained by mating huTSLP mice (catalog No.: C001809) with hTSLPR mice (catalog No.: C001942).
Figure 1. Gene editing strategy of huTSLP mice. The mouse Tslp endogenous domain was replaced with the human TSLP domain. The murine signal peptide was preserved.
Figure 2. Gene editing strategy of hTSLPR mice. Part of exon 1 to intron 7 of Mouse Crlf2 was replaced with Human CRLF2 CDS-Mouse Crlf2 CDS cassette.
Application Area
Screening, development, and safety evaluation of TSLP/TSLPR-targeted drugs;
Mechanism research and development of treatment methods for allergic diseases, inflammations, and autoimmune diseases.
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.