huIL5/huIL5RA Mouse
Product Name
huIL5/huIL5RA Mouse
Product ID
C002042
Strain Name
C57BL/6NCya-Il5tm1(hIL5)Il5ratm1(hIL5RA)/Cya
Backgroud
C57BL/6NCya
Status
When using this mouse strain in a publication, please cite “huIL5/huIL5RA Mouse (Catalog C002042) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Gene Name
IL5 & IL5RA
Gene Alias
EDF, TRF, IL-5, IL5R, CD125, CDw125, HSIL5R3
NCBI ID
Chromosome
Chr 5 (Human), Chr 3 (Human)
Datasheet
Strain Description
The huIL5/huIL5RA mouse is a dual-gene humanized model obtained by mating huIL5 mice (Catalog No.: C001813) with huIL5RA mice (Catalog No.: C002007). This model is applicable to the screening of human IgG antibody drug candidates, as well as the evaluation of pharmacology, pharmacodynamics, and pharmacokinetics. It serves as a valuable tool for advancing research in immunotherapies for allergic diseases and the mechanisms of Th2-type immune responses.
Strain Strategy
The huIL5/huIL5RA mice are a dual-gene humanized model obtained by mating huIL5 mice (Catalog No.: C001813) with huIL5RA mice (Catalog No.: C002007).
Figure 1. Gene editing strategy for huIL5 mice. The sequences from the start codon to the stop codon of the endogenous mouse Il5 gene were replaced with the sequences from the start codon to the stop codon of the human IL5 gene.
Figure 2. Gene editing strategy of huIL5RA mice.The mouse Il5ra endogenous extracellular domain was replaced with the human IL5RA extracellular domain. The murine transmembrane-cytoplasmic region was preserved.
Application Area
Screening, development, and preclinical evaluation of IL5/IL5RA-targeted therapeutics;
Assessment of allergic diseases immunotherapy and research into immune system mechanisms;
Development and screening of IgG antibody drug candidates;
Pharmacological, pharmacodynamic, and pharmacokinetic studies of IgG antibody drugs.
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