huSLC6A19/Pah-R243Q Mouse
Product Name
huSLC6A19/Pah-R243Q Mouse
Product ID
C002064
Strain Name
C57BL/6NCya-Slc6a19tm1(hSLC6A19)Pahem2(R243Q)/Cya
Backgroud
C57BL/6NCya
Status
When using this mouse strain in a publication, please cite “huSLC6A19/Pah-R243Q Mouse (Catalog C002064) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Gene Name
Pah & SLC6A19
Gene Alias
HND, B0AT1
NCBI ID
Chromosome
Chr 10 (Mouse), Chr 5 (Human)
MGI ID
Datasheet
Strain Description
The huSLC6A19/Pah-R243Q mouse was generated by crossing the huSLC6A19 mice (catalog No.: C002000) with Pah-R243Q mice (catalog No.: C001738). This model is suitable for research on phenylketonuria (PKU), amino acid metabolism disorders, as well as the screening and preclinical evaluation of SLC6A19 inhibitors.
Strain Strategy
Obtained by crossing huSLC6A19 mice (Catalog No.: C002000) with Pah-R243Q mice (Catalog No.: C001738).
Figure 1. Gene editing strategy of huSLC6A19 mice. The sequences from the start codon to 3'UTR of the endogenous mouse Slc6a19 gene were replaced with the sequences from the start codon to 3'UTR of the human SLC6A19 gene. The expression of mouse Slc6a19os may be affected by this KI region.
Figure 2. Gene editing strategy of Pah-R243Q mice. The p.R243Q (CGT to CAA) point mutation was introduced into exon 7 of the mouse Pah gene.
Application Area
Screening, development, and preclinical evaluation of SLC6A19 and Pah-R243Q targeted drugs;
Research on the phenylketonuria (PKU);
Research on amino acid metabolism disorders;
Screening and preclinical evaluation of SLC6A19 inhibitors.
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