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SD-H11-hREN
Product ID:
CR009
Background:
SD
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Strain Description
SD-H11-hREN rats are a humanized model generated using gene editing technology, in which the “3 kb of 5’- flanking sequence-Human REN DNA-1.2 kb of 3'-flanking sequence” cassette was inserted into H11 locus. Homozygous SD-H11-hREN rats are viable and fertile. This model can be used for research on the regulation of blood pressure, body fluid, and electrolyte homeostasis, as well as for studying the pathogenic mechanisms and drug development for various hereditary kidney diseases such as renal tubular dysgenesis and familial hyperreninemia.
Application Area
Area
REN-targeted drug screening, development, and evaluation
Area
Research on homeostatic regulation of blood pressure, body fluids, and electrolytes
Area
Research on the pathological mechanisms and therapeutic approaches of various hereditary kidney diseases such as renal tubular dysgenesis and familial hyperreninemia
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