SD-H11-hREN
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
SD-H11-hREN
Product ID
CR009
Gene Name
Background
SD
Gene Alias
RTD; HNFJ2; ADTKD4
Classification
Metabolic Target Humanized Models,Full-Gene Humanized Models,Metabolic Disease Models
NCBI ID
Phenotype
Chromosome
1
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Note: When using this mouse strain in a publication, please cite “SD-H11-hREN mice (Catalog CR009) were purchased from Cyagen.”
Strain Description
SD-H11-hREN rats are a humanized model generated using gene editing technology, in which the “3 kb of 5’- flanking sequence-Human REN DNA-1.2 kb of 3'-flanking sequence” cassette was inserted into H11 locus. Homozygous SD-H11-hREN rats are viable and fertile. This model can be used for research on the regulation of blood pressure, body fluid, and electrolyte homeostasis, as well as for studying the pathogenic mechanisms and drug development for various hereditary kidney diseases such as renal tubular dysgenesis and familial hyperreninemia.
Application Area
REN-targeted drug screening, development, and evaluation
Research on homeostatic regulation of blood pressure, body fluids, and electrolytes
Research on the pathological mechanisms and therapeutic approaches of various hereditary kidney diseases such as renal tubular dysgenesis and familial hyperreninemia
Validation Data