H11-hB2M & HLA-A24
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Genotype
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Basic Information
Model Name
H11-hB2M & HLA-A24
Product ID
I001137
Background
C57BL/6NCya
Gene Alias
IMD43; AMYLD6; MHC1D4; HLAA
Classification
Other Target Humanized Models,Autoimmune Disease Models
Phenotype
--
Chromosome
15
Document
Note: When using this mouse strain in a publication, please cite “H11-hB2M & HLA-A24 mice (Catalog I001137) were purchased from Cyagen.”
Strain Description
HLA-A24 (A24) is a human leukocyte antigen of the HLA-A serotype group, with its alpha chain encoded by the HLA-A*24 allele and its beta chain encoded by the B2M gene. The H11-hB2M&HLA-A24 mouse model is constructed by integrating the chimeric H2-K1 HLA-A24 gene into the H11 safe harbor locus of mice using gene editing technology. This humanized model can be used to identify viral peptides that express HLA-A24 binding sequences.
Application Area
Research on human viral infectious diseases
Development and testing of novel viral vaccines
Safety and immunogenicity testing of drugs and vaccines
Research on oncology and autoimmune diseases
Study of the interactions between human immune cells and pathogens
Research on homologous tumor transplantation (Syngeneic)
Validation Data