H11-hB2M & HLA-A2.1
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Genotype
Sex
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Basic Information
Model Name
H11-hB2M & HLA-A2.1
Product ID
I001138
Background
C57BL/6NCya
Gene Alias
IMD43; AMYLD6; MHC1D4; HLAA
Classification
Other Target Humanized Models,Autoimmune Disease Models
Phenotype
Chromosome
15
Document
Note: When using this mouse strain in a publication, please cite “H11-hB2M & HLA-A2.1 mice (Catalog I001138) were purchased from Cyagen.”
Strain Description
HLA-A2.1 is a subtype of class I HLA and one of the most common HLA subtypes globally. The H11-hB2M&HLA-A2.1 mouse model is constructed by integrating the chimeric H2-K1 HLA-A2.1 gene into the H11 safe harbor locus of mice using gene editing technology. This humanized model can play a significant role in studying the determinants of HLA-A2.1-restricted cytotoxic T cells (CTLs) and in the development of potential viral vaccines.
Application Area
Research on human viral infectious diseases
Development and testing of novel viral vaccines
Safety and immunogenicity testing of drugs and vaccines
Research on oncology and autoimmune diseases
Study of the interactions between human immune cells and pathogens
Research on homologous tumor transplantation (Syngeneic)
Validation Data