H11-hB2M & HLA-A2.1
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Strain Description
HLA-A2.1 is a subtype of class I HLA and one of the most common HLA subtypes globally. The H11-hB2M&HLA-A2.1 mouse model is constructed by integrating the chimeric H2-K1 HLA-A2.1 gene into the H11 safe harbor locus of mice using gene editing technology. This humanized model can play a significant role in studying the determinants of HLA-A2.1-restricted cytotoxic T cells (CTLs) and in the development of potential viral vaccines.
Application Area
Research on human viral infectious diseases
Development and testing of novel viral vaccines
Safety and immunogenicity testing of drugs and vaccines
Research on oncology and autoimmune diseases
Study of the interactions between human immune cells and pathogens
Research on homologous tumor transplantation (Syngeneic)
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