HLA-A11 is one of the most common HLA class I alleles and is associated with infectious diseases (such as familial otosclerosis, pulmonary tuberculosis, and leprosy), tumors, and autoimmune diseases. The H11-hB2M&HLA-A11 mouse model is constructed by integrating the chimeric H2-K1 HLA-A11 gene into the H11 safe harbor locus of mice using gene editing technology. This mouse model can be used to identify viral peptides that express HLA-A11 binding sequences.