H11-hB2M & HLA-A11
Product Type
Age
Genotype
Sex
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Basic Information
Model Name
H11-hB2M & HLA-A11
Product ID
I001139
Background
C57BL/6NCya
Gene Alias
IMD43; AMYLD6; MHC1D4; HLAA
Classification
Other Target Humanized Models,Autoimmune Disease Models
Phenotype
--
Chromosome
15
Document
Note: When using this mouse strain in a publication, please cite “H11-hB2M & HLA-A11 mice (Catalog I001139) were purchased from Cyagen.”
Strain Description
HLA-A11 is one of the most common HLA class I alleles and is associated with infectious diseases (such as familial otosclerosis, pulmonary tuberculosis, and leprosy), tumors, and autoimmune diseases. The H11-hB2M&HLA-A11 mouse model is constructed by integrating the chimeric H2-K1 HLA-A11 gene into the H11 safe harbor locus of mice using gene editing technology. This mouse model can be used to identify viral peptides that express HLA-A11 binding sequences.
Application Area
Research on human viral infectious diseases
Development and testing of novel viral vaccines
Safety and immunogenicity testing of drugs and vaccines
Research on oncology and autoimmune diseases
Study of the interactions between human immune cells and pathogens
Research on homologous tumor transplantation (Syngeneic)
Validation Data