The partial coding region of exon 2 of the mouse Ins1 gene was replaced with the "Kozak-CreERT2-WPRE-BGH pA" cassette. CreERT2 recombinase is expressed under the regulatory control of Ins1 gene elements. This model is a Tamoxifen-inducible Cre mouse, and when crossed with mice containing loxP sites, the offspring mice are expected to undergo sequence recombination between loxP sites mediated by Cre recombinase in the pancreas following T amoxifen induction.