Rosa26-hHRAS
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Model Name
Rosa26-hHRAS
Product ID
I001213
Gene Name
Background
C57BL/6JCya
Gene Alias
CTLO; HAMSV; HRAS1; RASH1; p21ras; C-H-RAS; H-RASIDX; C-BAS/HAS; C-HA-RAS1
Classification
Full-Gene Humanized Models
NCBI ID
Phenotype
Chromosome
11
Document
Note: When using this mouse strain in a publication, please cite “Rosa26-hHRAS mice (Catalog I001213) were purchased from Cyagen.”
Strain Description
The Rosa26-hHRAS mouse model is a humanized model constructed by integrating a human HRAS gene with the c.450+180A>G mutation into the Rosa26 safe harbor site in mice using gene editing technology. The introduction of the c.450+180A>G mutation significantly enhances HRAS gene expression. This model can be used for rapid in vivo testing of the carcinogenicity of genotoxic and non-genotoxic compounds, studying the impact of HRAS oncogene point mutations on tumorigenesis and development, and developing tumor prevention or suppression therapies.
Application Area
Rapid in vivo test for carcinogenicity of genotoxic and non-genotoxic compounds
Impact of HRAS oncogene point mutations on tumorigenesis and development
Validation Data