B6-htau/hGLP-1R
Product Type
Age
Genotype
Sex
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Basic Information
Model Name
B6-htau/hGLP-1R
Product ID
I001221
Background
C57BL/6Cya
Gene Alias
TAU; FTD1; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; tau-40; FTDP-17; PPP1R103; Tau-PHF6; GLP-1; GLP-1R; GLP-1-R
Classification
Metabolic Target Humanized Models,Full-Gene Humanized Models,Metabolic Disease Models,Neurological Disease Models
Chromosome
17
Document
Note: When using this mouse strain in a publication, please cite “B6-htau/hGLP-1R mice (Catalog I001221) were purchased from Cyagen.”
Strain Description
The B6-htau/hGLP-1R mouse is obtained by mating B6-htau mice (Catalog No.: C001410) with B6-hGLP-1R mice (Catalog No.: C001421). This model can be used for research on neurodegenerative diseases such as frontotemporal dementia (FTD) and Alzheimer's disease (AD), as well as metabolic diseases such as obesity and type 2 diabetes. It is also useful for developing GLP-1 receptor agonist (GLP-1RA) drugs or for the preclinical evaluation of the potential therapeutic effects of GLP-1RA drugs in tauopathy-related diseases like Alzheimer's disease (AD).
Application Area
Research on neurodegenerative diseases such as frontotemporal dementia (FTD) and Alzheimer's disease (AD)
Research on metabolic diseases such as obesity and type 2 diabetes
Evaluation of the potential therapeutic effects of GLP-1 receptor agonist (GLP-1RA) drugs on Alzheimer's disease (AD)
Development of GLP-1RA drugs
Validation Data