C57BL/6JCya-Krtap10-4em1flox/Cya
Common Name:
Krtap10-4-flox
Product ID:
S-CKO-00083
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Krtap10-4-flox
Strain ID
CKOCMP-100191037-Krtap10-4-B6J-VA
Gene Name
Product ID
S-CKO-00083
Gene Alias
675238; A030009A09Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
10
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Krtap10-4em1flox/Cya mice (Catalog S-CKO-00083) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000092369
NCBI RefSeq
NM_001135991.1
Target Region
Exon 1
Size of Effective Region
~2.3 kb
Detailed Document
Overview of Gene Research
Krtap10-4, also known as Keratin-associated protein 10-4, is a gene, though its exact function, associated pathways, and overall biological importance are not comprehensively detailed from the given information. However, genetic studies can be valuable in elucidating its role.
A study identified Krtap10-4 (rs201441480) as one of the eight new genotypes and their associated genes related to major adverse cardiovascular events (MACE) in patients with acute coronary syndromes (ACS) who were treated with clopidogrel and aspirin. This discovery was made through a two-stage large-scale sequencing data, including high-depth whole exome sequencing of 168 patients in the discovery cohort and high-depth targeted sequencing of 1793 patients in the replication cohort [1].
In conclusion, while the exact biological functions of Krtap10-4 are yet to be fully explored, the discovery of its association with MACE in ACS patients provides a starting point for further research. Understanding the role of Krtap10-4 in this context may contribute to better understanding the pathogenesis of cardiovascular outcomes and potentially guide therapeutic interventions for ACS patients.
References：
1. Liu, Xiaomin, Xu, Hanshi, Xu, Huaiqian, Liu, Xiao, Zhong, Shilong. 2021. New genetic variants associated with major adverse cardiovascular events in patients with acute coronary syndromes and treated with clopidogrel and aspirin. In The pharmacogenomics journal, 21, 664-672. doi:10.1038/s41397-021-00245-5. https://pubmed.ncbi.nlm.nih.gov/34158603/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen