C57BL/6JCya-Gramd2bem1flox/Cya
Common Name:
Gramd2b-flox
Product ID:
S-CKO-00538
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Gramd2b-flox
Strain ID
CKOCMP-107022-Gramd2b-B6J-VA
Gene Name
Product ID
S-CKO-00538
Gene Alias
9030613F08Rik; 9130427A09Rik; Gramd3; NS3TP2
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
18
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Gramd2bem1flox/Cya mice (Catalog S-CKO-00538) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000070166
NCBI RefSeq
NM_026240
Target Region
Exon 5
Size of Effective Region
~1.8 kb
Detailed Document
Overview of Gene Research
GRAMD2B, also known as Gem-associated protein 2 domain containing 2B, has not had its essential function, associated pathways, and overall biological importance widely established in the provided reference. However, genetic models can potentially be valuable in uncovering these aspects [1].
The reference only mentions that the rs2112481 on the GRAMD2B promoter was associated with serum leucocyte concentration in a genome-wide association study on coronary artery disease in type 1 diabetes [1].
In conclusion, the limited information from the study shows an association between a GRAMD2B promoter variant and serum leucocyte concentration in the context of type 1 diabetes-related coronary artery disease. Further research using gene knockout or conditional knockout mouse models could potentially reveal more about the essential biological functions of GRAMD2B and its role in this disease area.
References：
1. Antikainen, Anni A V, Sandholm, Niina, Trégouët, David-Alexandre, Rossing, Peter, Groop, Per-Henrik. . Genome-wide association study on coronary artery disease in type 1 diabetes suggests beta-defensin 127 as a risk locus. In Cardiovascular research, 117, 600-612. doi:10.1093/cvr/cvaa045. https://pubmed.ncbi.nlm.nih.gov/32077919/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen