C57BL/6JCya-Foxp1em1flox/Cya
Common Name:
Foxp1-flox
Product ID:
S-CKO-00676
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Foxp1-flox
Strain ID
CKOCMP-108655-Foxp1-B6J-VA
Gene Name
Product ID
S-CKO-00676
Gene Alias
3110052D19Rik; 4932443N09Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
6
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Foxp1em1flox/Cya mice (Catalog S-CKO-00676) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000113322
NCBI RefSeq
NM_053202
Target Region
Exon 8
Size of Effective Region
~0.7 kb
Detailed Document
Overview of Gene Research
Foxp1, short for forkhead box protein P1, is a transcription factor encoding gene crucial for the early development of multiple organ systems, including the brain [5]. It is involved in diverse biological processes and associated with various pathways. Genetic models, such as knockout (KO) mouse models, are valuable tools for studying its functions.
In ovarian aging, Foxp1 declines with age and inhibits CDKN1A transcription. Silencing Foxp1 in mice leads to premature ovarian insufficiency, suggesting its role as a regulator of ovarian aging [1].
In atherosclerosis, endothelial-specific Foxp1 knockout (Foxp1ECKO) in ApoeKO mice shows increased atherosclerotic lesion formation, while endothelial-specific Foxp1 overexpression reduces it. Foxp1 directly regulates endothelial inflammasome components, acting as a gatekeeper of vessel inflammation [2].
In FOXP1 syndrome caused by haploinsufficiency of the Foxp1 gene, Foxp1+/- mice exhibit mitochondrial dysfunction, oxidative stress, and subsequent cognitive and motor impairment [3].
In primate cardiac aging, FOXP1 is a key downregulated factor in aged cardiomyocytes, and its deficiency leads to hypertrophic and senescent phenotypes in human embryonic stem cell-derived cardiomyocytes [4].
In conclusion, Foxp1 is essential for normal development and physiological functions. Studies using KO/CKO mouse models have revealed its significance in diseases like ovarian aging, atherosclerosis, FOXP1 syndrome, and cardiac aging. Understanding Foxp1's functions provides insights into disease mechanisms and potential therapeutic targets for these conditions.
References：
1. Wu, Meng, Tang, Weicheng, Chen, Ying, Qiao, Huiying, Wang, Shixuan. 2024. Spatiotemporal transcriptomic changes of human ovarian aging and the regulatory role of FOXP1. In Nature aging, 4, 527-545. doi:10.1038/s43587-024-00607-1. https://pubmed.ncbi.nlm.nih.gov/38594460/
2. Zhuang, Tao, Liu, Jie, Chen, Xiaoli, Reilly, Muredach, Zhang, Yuzhen. 2019. Endothelial Foxp1 Suppresses Atherosclerosis via Modulation of Nlrp3 Inflammasome Activation. In Circulation research, 125, 590-605. doi:10.1161/CIRCRESAHA.118.314402. https://pubmed.ncbi.nlm.nih.gov/31318658/
3. Wang, Jing, Fröhlich, Henning, Torres, Felipe Bodaleo, Agarwal, Amit, Rappold, Gudrun A. . Mitochondrial dysfunction and oxidative stress contribute to cognitive and motor impairment in FOXP1 syndrome. In Proceedings of the National Academy of Sciences of the United States of America, 119, . doi:10.1073/pnas.2112852119. https://pubmed.ncbi.nlm.nih.gov/35165191/
4. Zhang, Yiyuan, Zheng, Yandong, Wang, Si, Ma, Shuai, Qu, Jing. . Single-nucleus transcriptomics reveals a gatekeeper role for FOXP1 in primate cardiac aging. In Protein & cell, 14, 279-293. doi:10.1093/procel/pwac038. https://pubmed.ncbi.nlm.nih.gov/37084237/
5. Lozano, Reymundo, Gbekie, Catherine, Siper, Paige M, Buxbaum, Joseph D, Kolevzon, Alexander. 2021. FOXP1 syndrome: a review of the literature and practice parameters for medical assessment and monitoring. In Journal of neurodevelopmental disorders, 13, 18. doi:10.1186/s11689-021-09358-1. https://pubmed.ncbi.nlm.nih.gov/33892622/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen