C57BL/6JCya-Fabp4em1flox/Cya
Common Name:
Fabp4-flox
Product ID:
S-CKO-01230
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Fabp4-flox
Strain ID
CKOCMP-11770-Fabp4-B6J-VA
Gene Name
Product ID
S-CKO-01230
Gene Alias
422/aP2; AFABP; ALBP; ALBP/Ap2; Ap2; Lbpl; P15
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
3
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Fabp4em1flox/Cya mice (Catalog S-CKO-01230) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000029041
NCBI RefSeq
NM_024406
Target Region
Exon 2
Size of Effective Region
~2.1 kb
Detailed Document
Overview of Gene Research
Fabp4, also known as fatty acid binding protein 4 or aP2, is a cytoplasmic fatty acid chaperone. It is highly expressed in adipose tissue and myeloid cells, functioning as a lipid chaperone protein and playing a role in lipid metabolism. It impacts cells through JAK2/STAT2 and c-kit pathways, and is involved in processes like angiogenesis, vascular smooth muscle cell proliferation and migration. Additionally, it is a secreted hormone maintaining glucose homeostasis [2,5,6].
In ovarian cancer cells, knockdown of FABP4 led to increased 5-hydroxymethylcytosine levels in the DNA, downregulation of metastasis-associated gene signatures, and reduced clonogenic cell survival. CRISPR-mediated knockout in high-grade serous ovarian cancer cells decreased metastatic tumor burden in mice [1]. In elderly mice, silencing FABP4 rejuvenated aging-associated decline in metabolic activities, reversing metabolic disorders by promoting cholesterol and fatty acid degradation and suppressing gluconeogenesis [3]. In TNBC, knocking down Fabp4 or inhibiting its activity suppressed tumor progression in mouse models [4].
In conclusion, Fabp4 is crucial in lipid metabolism and glucose homeostasis. Gene-knockout models in mice have revealed its role in various disease conditions such as ovarian cancer metastasis, aging-associated metabolic disorders, and TNBC progression. These findings highlight its potential as a therapeutic target in these disease areas.
References:
1. Mukherjee, Abir, Chiang, Chun-Yi, Daifotis, Helen A, Fiehn, Oliver, Lengyel, Ernst. 2020. Adipocyte-Induced FABP4 Expression in Ovarian Cancer Cells Promotes Metastasis and Mediates Carboplatin Resistance. In Cancer research, 80, 1748-1761. doi:10.1158/0008-5472.CAN-19-1999. https://pubmed.ncbi.nlm.nih.gov/32054768/
2. Garin-Shkolnik, Tali, Rudich, Assaf, Hotamisligil, Gökhan S, Rubinstein, Menachem. 2013. FABP4 attenuates PPARγ and adipogenesis and is inversely correlated with PPARγ in adipose tissues. In Diabetes, 63, 900-11. doi:10.2337/db13-0436. https://pubmed.ncbi.nlm.nih.gov/24319114/
3. Lv, Jian, Hu, Yimeng, Li, Lili, Tang, Lixu, Wang, Zhihua. 2023. Targeting FABP4 in elderly mice rejuvenates liver metabolism and ameliorates aging-associated metabolic disorders. In Metabolism: clinical and experimental, 142, 155528. doi:10.1016/j.metabol.2023.155528. https://pubmed.ncbi.nlm.nih.gov/36842611/
4. Yu, Liya, Wei, Wei, Lv, Jian, Wang, Zhihua, Cai, Cheguo. 2024. FABP4-mediated lipid metabolism promotes TNBC progression and breast cancer stem cell activity. In Cancer letters, 604, 217271. doi:10.1016/j.canlet.2024.217271. https://pubmed.ncbi.nlm.nih.gov/39306229/
5. van der Ark-Vonk, Ellen M, Puijk, Mike V, Pasterkamp, Gerard, van der Laan, Sander W. 2024. The Effects of FABP4 on Cardiovascular Disease in the Aging Population. In Current atherosclerosis reports, 26, 163-175. doi:10.1007/s11883-024-01196-5. https://pubmed.ncbi.nlm.nih.gov/38698167/
6. Prentice, Kacey J, Saksi, Jani, Hotamisligil, Gökhan S. 2019. Adipokine FABP4 integrates energy stores and counterregulatory metabolic responses. In Journal of lipid research, 60, 734-740. doi:10.1194/jlr.S091793. https://pubmed.ncbi.nlm.nih.gov/30705117/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen