Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6NCya-Bcl6em1flox/Cya
Common Name:
Bcl6-flox
Product ID:
S-CKO-01403
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Bcl6-flox
Strain ID
CKOCMP-12053-Bcl6-B6N-VA
Gene Name
Bcl6
Product ID
S-CKO-01403
Gene Alias
Bcl5
Background
C57BL/6NCya
NCBI ID
12053
Modification
Conditional knockout
Chromosome
16
Phenotype
MGI:107187
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Bcl6em1flox/Cya mice (Catalog S-CKO-01403) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000023151
NCBI RefSeq
NM_009744
Target Region
Exon 5~6
Size of Effective Region
~2.3 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Bcl6, also known as B-cell lymphoma 6, is a transcriptional repressor that plays a crucial role in the development and maintenance of germinal centers (GCs), which are essential for an effective humoral immune response [2]. It is also involved in many other biological processes such as cell proliferation, survival, differentiation, migration, and invasion [1]. Genomic aberrations of Bcl6 can lead to the development of GC-derived lymphomas and it is considered a key oncogene in various cancers [2,5].

In mouse models, deletion of Bcl6 in lymphoid tissue inducer-like ILC3s resulted in dysregulation of the transcriptional program and enhanced expression of interleukin-17A (IL-17A) and IL-17F, associated with worsened inflammation in a colitis model, indicating its role in ILC3 subset biology [4]. In gastrointestinal stromal tumor (GIST) cells, induction of Bcl6 by imatinib mesylate (IM) treatment led to suppression of apoptosis and IM resistance. Targeting Bcl6 with an inhibitor, BI-3802, restored IM sensitivity and showed synergy with IM in vitro and in vivo, suggesting Bcl6's role in IM resistance [3].

In conclusion, Bcl6 is a critical regulator in immunity and tumorigenesis. Its functions in immune cell development, especially in GCs, are well-established. In disease areas such as lymphoma, GIST, and pre-eclampsia, studies using gene knockout or conditional knockout mouse models have revealed its roles in promoting tumor progression, drug resistance, and placental/endometrial pathophysiology, providing potential therapeutic targets for these diseases [1,2,3].

References:
1. Louwen, Frank, Kreis, Nina-Naomi, Ritter, Andreas, Solbach, Christine, Yuan, Juping. . BCL6, a key oncogene, in the placenta, pre-eclampsia and endometriosis. In Human reproduction update, 28, 890-909. doi:10.1093/humupd/dmac027. https://pubmed.ncbi.nlm.nih.gov/35640966/
2. Leeman-Neill, Rebecca J, Bhagat, Govind. 2018. BCL6 as a therapeutic target for lymphoma. In Expert opinion on therapeutic targets, 22, 143-152. doi:10.1080/14728222.2018.1420782. https://pubmed.ncbi.nlm.nih.gov/29262721/
3. Zeng, Xiangyu, Zhao, Fei, Jia, Jie, Lou, Zhenkun, Zhang, Peng. . Targeting BCL6 in Gastrointestinal Stromal Tumor Promotes p53-Mediated Apoptosis to Enhance the Antitumor Activity of Imatinib. In Cancer research, 83, 3624-3635. doi:10.1158/0008-5472.CAN-23-0082. https://pubmed.ncbi.nlm.nih.gov/37556508/
4. Tachó-Piñot, Roser, Stamper, Christopher T, King, James I, Withers, David R, Hepworth, Matthew R. 2023. Bcl6 is a subset-defining transcription factor of lymphoid tissue inducer-like ILC3. In Cell reports, 42, 113425. doi:10.1016/j.celrep.2023.113425. https://pubmed.ncbi.nlm.nih.gov/37950867/
5. McLachlan, Tabitha, Matthews, William C, Jackson, Evangeline R, Germon, Zacary P, Dun, Matthew D. . B-cell Lymphoma 6 (BCL6): From Master Regulator of Humoral Immunity to Oncogenic Driver in Pediatric Cancers. In Molecular cancer research : MCR, 20, 1711-1723. doi:10.1158/1541-7786.MCR-22-0567. https://pubmed.ncbi.nlm.nih.gov/36166198/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest