C57BL/6JCya-Cd38em1flox/Cya
Common Name
Cd38-flox
Product ID
S-CKO-01622
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-12494-Cd38-B6J-VA
When using this mouse strain in a publication, please cite “Cd38-flox Mouse (Catalog S-CKO-01622) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Cd38-flox
Strain ID
CKOCMP-12494-Cd38-B6J-VA
Gene Name
Product ID
S-CKO-01622
Gene Alias
I-19, ADPRC 1, Cd38-rs1
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 5
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000030964
NCBI RefSeq
NM_007646
Target Region
Exon 2~3
Size of Effective Region
~1.7 kb
Overview of Gene Research
Cd38, a transmembrane glycoprotein, can act as an enzyme with NAD-depleting and intracellular signaling activity, or as a receptor with adhesive functions [2]. It is widely expressed in hematopoietic cells, multiple myeloma (MM) cells, and some non-hematopoietic tissues [3,5]. Cd38 is involved in regulating intracellular nicotinamide adenine dinucleotide (NAD+) levels, which is crucial for various cellular functions and signaling pathways [1,2,6,7].
Cd38 knockout (KO) mouse models have shown significant protective effects against neurodegenerative and neuroinflammatory insults [1]. In the context of ovarian aging, CD38 deletion mitigated ovarian aging, preserving fertility and follicle reserve in aged mice by countering age-related gene expression changes and intercellular communication alterations [4]. Also, inflammation-induced increase in CD38 in immune cells during aging leads to decreased NAD+ levels, and blocking its ecto-enzymatic activity can increase NAD+ [6].
In conclusion, Cd38 plays essential roles in multiple biological processes including neurodegeneration, neuroinflammation, ovarian aging, and immune cell function through its regulation of NAD+ levels. The use of Cd38 KO mouse models has provided valuable insights into its functions in these disease-related areas, highlighting its potential as a therapeutic target [1,4,6].
References：
1. Guerreiro, Serge, Privat, Anne-Laure, Bressac, Laurence, Toulorge, Damien. 2020. CD38 in Neurodegeneration and Neuroinflammation. In Cells, 9, . doi:10.3390/cells9020471. https://pubmed.ncbi.nlm.nih.gov/32085567/
2. Piedra-Quintero, Zayda L, Wilson, Zachary, Nava, Porfirio, Guerau-de-Arellano, Mireia. 2020. CD38: An Immunomodulatory Molecule in Inflammation and Autoimmunity. In Frontiers in immunology, 11, 597959. doi:10.3389/fimmu.2020.597959. https://pubmed.ncbi.nlm.nih.gov/33329591/
3. Gozzetti, Alessandro, Ciofini, Sara, Simoncelli, Martina, Raspadori, Donatella, Bocchia, Monica. 2022. Anti CD38 monoclonal antibodies for multiple myeloma treatment. In Human vaccines & immunotherapeutics, 18, 2052658. doi:10.1080/21645515.2022.2052658. https://pubmed.ncbi.nlm.nih.gov/35404740/
4. Yang, Qingling, Chen, Wenhui, Cong, Luping, Wei, Chenlu, Sun, Yingpu. 2023. NADase CD38 is a key determinant of ovarian aging. In Nature aging, 4, 110-128. doi:10.1038/s43587-023-00532-9. https://pubmed.ncbi.nlm.nih.gov/38129670/
5. van de Donk, Niels W C J, Richardson, Paul G, Malavasi, Fabio. 2017. CD38 antibodies in multiple myeloma: back to the future. In Blood, 131, 13-29. doi:10.1182/blood-2017-06-740944. https://pubmed.ncbi.nlm.nih.gov/29118010/
6. Chini, Claudia C S, Peclat, Thais R, Warner, Gina M, Baur, Joseph A, Chini, Eduardo N. 2020. CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels. In Nature metabolism, 2, 1284-1304. doi:10.1038/s42255-020-00298-z. https://pubmed.ncbi.nlm.nih.gov/33199925/
7. Kar, Anwesha, Mehrotra, Shikhar, Chatterjee, Shilpak. 2020. CD38: T Cell Immuno-Metabolic Modulator. In Cells, 9, . doi:10.3390/cells9071716. https://pubmed.ncbi.nlm.nih.gov/32709019/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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