C57BL/6JCya-Embem1flox/Cya
Common Name:
Emb-flox
Product ID:
S-CKO-02190
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Emb-flox
Strain ID
CKOCMP-13723-Emb-B6J-VA
Gene Name
Product ID
S-CKO-02190
Gene Alias
Gp70
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
13
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Embem1flox/Cya mice (Catalog S-CKO-02190) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000022242
NCBI RefSeq
NM_010330
Target Region
Exon 5
Size of Effective Region
~0.6 kb
Detailed Document
Overview of Gene Research
Embigin (EMB) is a transmembrane glycoprotein. In glioblastoma multiforme (GBM), its high expression is associated with poor prognosis. EMB promotes GBM progression by upregulating epithelial-mesenchymal transition (EMT) and glycolysis, and maintaining glutathione (GSH) redox balance via inducing monocarboxylate transporter 4 (MCT4) and glutathione peroxidase 3 (GPX3) expression [1].
In maize, EMB-7L is essential for embryogenesis and plant development. It encodes a chloroplast-localized P-type pentatricopeptide repeat (PPR) protein. Mutations in EMB-7L lead to severe chloroplast deficiency, affecting chloroplast protein-encoding gene transcription, pre-mRNA intron splicing, chloroplast structure and activity [2].
In conclusion, EMB plays diverse and crucial roles in different organisms. In GBM, it serves as an independent prognostic biomarker and a potential therapeutic target. In maize, it is vital for embryogenesis and plant development through its influence on chloroplast-related processes. These findings from different research models contribute to our understanding of biological functions and disease mechanisms related to EMB.
References：
1. Cheng, Bo, Liu, Jing, Gao, Ling, Liu, Shangqi, Wu, Xiaojin. 2025. EMB-driven glioblastoma multiforme progression via the MCT4/GPX3 axis: therapeutic inhibition by Ganxintriol A. In Journal of translational medicine, 23, 272. doi:10.1186/s12967-025-06290-z. https://pubmed.ncbi.nlm.nih.gov/40038742/
2. Yuan, Ningning, Wang, Jiechen, Zhou, Yong, Wang, Wenqin, Wu, Yongrui. 2019. EMB-7L is required for embryogenesis and plant development in maize involved in RNA splicing of multiple chloroplast genes. In Plant science : an international journal of experimental plant biology, 287, 110203. doi:10.1016/j.plantsci.2019.110203. https://pubmed.ncbi.nlm.nih.gov/31481208/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen