C57BL/6NCya-Celf2em1flox/Cya
Common Name:
Celf2-flox
Product ID:
S-CKO-02268
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Celf2-flox
Strain ID
CKOCMP-14007-Celf2-B6N-VA
Gene Name
Product ID
S-CKO-02268
Gene Alias
B230218O03; B230345P09Rik; CELF-2; CUG-BP2; Cugbp2; D230046B21Rik; Etr-3; Napor; Napor-2; mETR-3
Background
C57BL/6NCya
NCBI ID
Modification
Conditional knockout
Chromosome
2
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Celf2em1flox/Cya mice (Catalog S-CKO-02268) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000114924
NCBI RefSeq
NM_001160293
Target Region
Exon 3
Size of Effective Region
~1.5 kb
Detailed Document
Overview of Gene Research
CELF2, also known as CUGBP ELAV-like family number 2, is an RNA-binding protein. It plays crucial roles in processes such as RNA splicing. It is involved in various biological pathways, and its dysregulation is associated with multiple diseases. Gene knockout (KO) and conditional knockout (CKO) mouse models are valuable for studying its functions [1-6].
In hematopoietic system KO mouse models, Celf2 deficiency enhanced HSCs self-renewal and myeloid cell differentiation, accelerating myeloid cell transformation and AML development through the FAT10-mTORC1 axis [1].
In Celf2 Nestin-Cre knockout mice, heterozygous knockout led to autism-like behaviors, with an underdeveloped cerebral cortex, reduced dendritic spine density, and affected synaptic maturation [2].
In conclusion, Celf2 is essential for normal biological processes, especially in hematopoiesis and neurodevelopment. KO and CKO mouse models have revealed its role in acute leukemia and autism-like behaviors, providing potential therapeutic targets for myeloid leukemia and insights into the mechanisms of autism-related disorders.
References：
1. Guo, Tengxiao, Wang, Yuxia, Sun, Xiaolu, Yuan, Weiping, Wang, Xiaomin. 2024. Loss of RNA-binding protein CELF2 promotes acute leukemia development via FAT10-mTORC1. In Oncogene, 43, 1476-1487. doi:10.1038/s41388-024-03006-3. https://pubmed.ncbi.nlm.nih.gov/38514854/
2. Duan, Xinyu, Peng, Xiaoxia, Jia, Xiangbin, Tan, Jieqiong, Hu, Zhangxue. 2024. CELF2 Deficiency Demonstrates Autism-Like Behaviors and Interferes with Late Development of Cortical Neurons in Mice. In Molecular neurobiology, 62, 156-168. doi:10.1007/s12035-024-04250-0. https://pubmed.ncbi.nlm.nih.gov/38829512/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen