Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Grik1em1flox/Cya
Common Name:
Grik1-flox
Product ID:
S-CKO-02750
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Grik1-flox
Strain ID
CKOCMP-14805-Grik1-B6J-VA
Gene Name
Grik1
Product ID
S-CKO-02750
Gene Alias
A830007B11Rik; D16Ium24; D16Ium24e; GluK1; GluK5; Glur-5; Glur5; Glurbeta1
Background
C57BL/6JCya
NCBI ID
14805
Modification
Conditional knockout
Chromosome
16
Phenotype
MGI:95814
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Grik1em1flox/Cya mice (Catalog S-CKO-02750) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000072256
NCBI RefSeq
NM_146072
Target Region
Exon 4
Size of Effective Region
~0.7 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Grik1, which encodes the GluK1 subunit of the excitatory kainate receptor, is essential for brain function and is involved in many mental and neurological diseases [3,4,5,6,7]. The kainate receptor is part of the ionotropic glutamate receptor family, and its signaling pathways are crucial for synaptic plasticity, learning, and memory processes [3,4].

In glioblastoma, knockdown of Grik1 retarded GBM cells growth, migration, and invasion, indicating that Grik1 promotes glioblastoma malignancy and may be a biomarker for diagnosis and therapy [2]. In endometriosis, while the study focused on lncRNA GRIK1-AS1, it's worth noting that GRIK1-AS1 deficiency accelerates endometriosis progression through epigenetic regulation mechanisms related to SFRP1 methylation [1]. In Attention deficit hyperactivity disorder (ADHD), Grik1 risk variants and Grik1 deficiency were detected in Indian ADHD probands, suggesting its role in ADHD etiology [4].

In conclusion, Grik1 is crucial for normal brain function and is implicated in multiple disease conditions such as glioblastoma, endometriosis, and ADHD. Functional studies, especially those involving loss-of-function experiments like knockdown in glioblastoma, have revealed its role in promoting disease-related cell behaviors. Research on Grik1 provides valuable insights into the mechanisms of these diseases and potential therapeutic targets.

References:
1. Liu, Wei, Hu, Bin, Wang, Xiaoli, Chen, Xuexing, Chen, Lijuan. 2023. GRIK1-AS1 deficiency accelerates endometriosis progression by boosting DNMT1-dependent SFRP1 promoter methylation in endometrial stromal cells. In The journal of gene medicine, 25, e3557. doi:10.1002/jgm.3557. https://pubmed.ncbi.nlm.nih.gov/37392032/
2. Hou, Guoqiang, Xu, Xinhang, Hu, Weixing. 2024. GRIK1 promotes glioblastoma malignancy and is a novel prognostic factor of poor prognosis. In Oncology research, 32, 727-736. doi:10.32604/or.2023.043391. https://pubmed.ncbi.nlm.nih.gov/38560566/
3. Lieberman, Richard, Jensen, Kevin P, Clinton, Kaitlin, Kranzler, Henry R, Covault, Jonathan. 2020. Molecular Correlates of Topiramate and GRIK1 rs2832407 Genotype in Pluripotent Stem Cell-Derived Neural Cultures. In Alcoholism, clinical and experimental research, 44, 1561-1570. doi:10.1111/acer.14399. https://pubmed.ncbi.nlm.nih.gov/32574382/
4. Chatterjee, Mahasweta, Saha, Sharmistha, Dutta, Nilanjana, Sinha, Swagata, Mukhopadhyay, Kanchan. 2022. Kainate receptor subunit 1 (GRIK1) risk variants and GRIK1 deficiency were detected in the Indian ADHD probands. In Scientific reports, 12, 18449. doi:10.1038/s41598-022-21948-0. https://pubmed.ncbi.nlm.nih.gov/36323684/
5. Kranzler, Henry R, Armeli, Stephen, Feinn, Richard, Gelernter, Joel, Covault, Jonathan. 2014. GRIK1 genotype moderates topiramate's effects on daily drinking level, expectations of alcohol's positive effects and desire to drink. In The international journal of neuropsychopharmacology, 17, 1549-56. doi:10.1017/S1461145714000510. https://pubmed.ncbi.nlm.nih.gov/24786948/
6. Kranzler, Henry R, Armeli, Stephen, Tennen, Howard, Gelernter, Joel, Covault, Jonathan. . GRIK1 genotype and daily expectations of alcohol's positive effects moderate the reduction of heavy drinking by topiramate. In Experimental and clinical psychopharmacology, 22, 494-501. doi:10.1037/a0038350. https://pubmed.ncbi.nlm.nih.gov/25436841/
7. Yang, Bao-Zhu, Arias, Albert J, Feinn, Richard, Gelernter, Joel, Petrakis, Ismene L. 2017. GRIK1 and GABRA2 Variants Have Distinct Effects on the Dose-Related Subjective Response to Intravenous Alcohol in Healthy Social Drinkers. In Alcoholism, clinical and experimental research, 41, 2025-2032. doi:10.1111/acer.13516. https://pubmed.ncbi.nlm.nih.gov/29131352/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest