C57BL/6JCya-Il16em1flox/Cya
Common Name
Il16-flox
Product ID
S-CKO-03086
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-16170-Il16-B6J-VA
Status
When using this mouse strain in a publication, please cite “Il16-flox Mouse (Catalog S-CKO-03086) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Il16-flox
Strain ID
CKOCMP-16170-Il16-B6J-VA
Gene Name
Product ID
S-CKO-03086
Gene Alias
mKIAA4048
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 7
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000001792
NCBI RefSeq
NM_010551
Target Region
Exon 3
Size of Effective Region
~0.6 kb
Overview of Gene Research
Il16, also known as interleukin 16, is a pro-inflammatory cytokine. It is synthesized as a precursor and processed into bioactive tetramers. IL16 functions through interaction with CD4, and is involved in processes such as chemotaxis induction, regulation of immune cell activation, and is associated with multiple biological pathways related to inflammation and immune responses [3,4].
In an in vivo study, IL16 knockout (KO) mice infected with Influenza A virus (IAV) showed an increase in the percentage of Th1 cells in the spleen and elevation of IFN-γ and TNF-α secretion from CD8+ T cells in the lungs and spleens, along with upregulated major histocompatibility complex II in the lungs, suggesting that IL16 deficiency enhances Th1 and cytotoxic T lymphocyte response as well as dendritic cell maturation upon IAV infection [2]. In a rat model of osteoarthritis (OA), IL16 was upregulated. Knockdown of IL16 downregulated the expression of MMP3 and MMP13, suggesting its role in OA progression [1].
In conclusion, Il16 plays a crucial role in regulating immune responses and inflammation. The study of Il16 KO mouse models has provided insights into its role in viral infection-related immune responses and OA progression, highlighting its importance in understanding these disease mechanisms.
References：
1. Luo, Ziwei, Han, Qianting, Lu, Jianghua, Liu, Aijun, Chen, Dongfeng. 2023. IL16 Regulates Osteoarthritis Progression as a Target Gene of Novel-miR-81. In Cartilage, 15, 175-183. doi:10.1177/19476035231168387. https://pubmed.ncbi.nlm.nih.gov/37086007/
2. Jia, Ran, Liu, Shuai, Xu, Jin, Liang, Xiaozhen. 2019. IL16 deficiency enhances Th1 and cytotoxic T lymphocyte response against influenza A virus infection. In Bioscience trends, 13, 516-522. doi:10.5582/bst.2019.01286. https://pubmed.ncbi.nlm.nih.gov/31852865/
3. Center, D M, Kornfeld, H, Cruikshank, W W. . Interleukin-16. In The international journal of biochemistry & cell biology, 29, 1231-4. doi:. https://pubmed.ncbi.nlm.nih.gov/9451819/
4. Cruikshank, W W, Kornfeld, H, Center, D M. . Interleukin-16. In Journal of leukocyte biology, 67, 757-66. doi:. https://pubmed.ncbi.nlm.nih.gov/10857846/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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