C57BL/6JCya-Il17aem1flox/Cya
Common Name
Il17a-flox
Product ID
S-CKO-03087
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-16171-Il17a-B6J-VA
Status
When using this mouse strain in a publication, please cite “Il17a-flox Mouse (Catalog S-CKO-03087) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Il17a-flox
Strain ID
CKOCMP-16171-Il17a-B6J-VA
Gene Name
Product ID
S-CKO-03087
Gene Alias
Il17, Ctla8, IL-17, Ctla-8, IL-17A
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 1
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000027061
NCBI RefSeq
NM_010552
Target Region
Exon 2
Size of Effective Region
~1.2 kb
Overview of Gene Research
Il17a, a major member of the IL-17 cytokine family, is mainly produced by T helper 17 (Th17) cells, with other cell types like CD8+ T cells also capable of its production. It has a host-protective capacity in healthy individuals but excessive elevation is linked to autoimmune diseases and cancer, playing a role in immune-related pathways [3].
In a COPD mouse model, selective knockout of Il17a in the airway epithelium significantly reduced neutrophilic infiltration, peribronchial inflammation, pro-inflammatory mediators, and mucus production. This shows that Il17a, expressed in the airway epithelium, can act in an autocrine manner to amplify inflammation and increase mucus production in COPD pathogenesis [1].
In HLA-B27 transgenic rats, a peptide-based vaccine targeting Il17a alleviated the spondyloarthritis phenotype, inhibiting enthesitis, bone destruction, and new bone formation [2].
In conclusion, Il17a is crucial in regulating immune-related processes. The gene knockout mouse models in COPD and spondyloarthritis research have revealed its role in promoting inflammation and disease-related phenotypes, highlighting its potential as a therapeutic target in these diseases.
References：
1. Wu, Mindan, Lai, Tianwen, Jing, Du, Wu, Xiaohong, Shen, Huahao. . Epithelium-derived IL17A Promotes Cigarette Smoke-induced Inflammation and Mucus Hyperproduction. In American journal of respiratory cell and molecular biology, 65, 581-592. doi:10.1165/rcmb.2020-0424OC. https://pubmed.ncbi.nlm.nih.gov/34186014/
2. Hayashi, Hiroki, Sun, Jiao, Yanagida, Yuka, Tomita, Tetsuya, Nakagami, Hironori. . Peptide-based vaccine targeting IL17A attenuates experimental spondyloarthritis in HLA-B27 transgenic rats. In RMD open, 9, . doi:10.1136/rmdopen-2022-002851. https://pubmed.ncbi.nlm.nih.gov/36737108/
3. Song, Meiying, Liang, Jie, Wang, Luoyang, Zhang, Li, Zhang, Bei. 2023. IL-17A functions and the therapeutic use of IL-17A and IL-17RA targeted antibodies for cancer treatment. In International immunopharmacology, 123, 110757. doi:10.1016/j.intimp.2023.110757. https://pubmed.ncbi.nlm.nih.gov/37579542/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.