C57BL/6JCya-Il4raem1flox/Cya
Common Name
Il4ra-flox
Product ID
S-CKO-03105
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-16190-Il4ra-B6J-VA
When using this mouse strain in a publication, please cite “Il4ra-flox Mouse (Catalog S-CKO-03105) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Il4ra-flox
Strain ID
CKOCMP-16190-Il4ra-B6J-VA
Gene Name
Product ID
S-CKO-03105
Gene Alias
Il4r, CD124
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 7
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000033004
NCBI RefSeq
NM_001008700
Target Region
Exon 4
Size of Effective Region
~1.8 kb
Overview of Gene Research
Il4ra, the interleukin-4 receptor alpha subunit, is crucial in immune-related processes. It is part of two receptor types that have different modulatory effects on immune responses. IL-4 and its receptor play important roles in the pathologies of asthma and atopy, with Il4ra being central to the signaling of IL-4 and IL-13, key drivers of type 2 inflammation [1,2].
In rhabdomyosarcoma (RMS), conditional deletion of Il4ra in genetically-engineered RMS mouse models altered the latency, site, and/or stage distribution of RMS tumors. In alveolar rhabdomyosarcoma (ARMS), satellite cell co-injection was necessary for Il4ra null tumor cells engraftment, while in embryonal rhabdomyosarcoma (ERMS), satellite cell co-injection decreased the latency of engraftment of Il4ra wild-type tumor cells but not Il4ra null tumor cells. This indicates that Il4ra is involved in the interaction between satellite cells and RMS tumor cells during tumor initiation [3].
In conclusion, Il4ra is essential for normal immune-related functions, especially in type 2 inflammation-associated processes. The study of Il4ra using gene-knockout mouse models in RMS has revealed its significance in tumor initiation and progression, providing insights into potential therapeutic targets for this disease.
References：
1. Danielewicz, Hanna, Dębińska, Anna, Drabik-Chamerska, Anna, Kalita, Danuta, Boznański, Andrzej. . IL4RA gene expression in relation to I50V, Q551R and C-3223T polymorphisms. In Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 30, 17-22. doi:10.17219/acem/127031. https://pubmed.ncbi.nlm.nih.gov/33529503/
2. McCann, Marc R, Kosloski, Matthew P, Xu, Christine, Davis, John D, Kamal, Mohamed A. . Dupilumab: Mechanism of action, clinical, and translational science. In Clinical and translational science, 17, e13899. doi:10.1111/cts.13899. https://pubmed.ncbi.nlm.nih.gov/39080841/
3. Edwards, David W, Kroepfl, Gabrielle M, Jackson, Jacob M, Michalek, Joel E, Keller, Charles. 2024. Developmental and therapeutic implications of IL4ra expression for rhabdomyosarcoma. In Transgenic research, 33, 229-241. doi:10.1007/s11248-024-00390-0. https://pubmed.ncbi.nlm.nih.gov/38851650/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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