Kl, also known as Klotho, is an anti-ageing gene that has been associated with multiple biological processes and diseases. It is involved in various pathways, and its genetic polymorphisms are of significance in understanding disease susceptibility. Genetic models, such as those exploring single nucleotide polymorphisms (SNPs), can help in studying its role in diseases [1].

KL SNPs have been found to be significantly associated with Type 2 Diabetes Mellitus (T2DM) in an Asian cohort. Odds ratios of these SNPs indicate an increased susceptibility to T2DM in additive and dominant models. The KL-FGF23-VD axis, related to the Kl gene, can alleviate the inflammatory response, reduce Aβ deposition, and inhibit the activation of the NF-κB pathway and neuron apoptosis in the brain tissue of rats with late-onset Alzheimer's disease (LOAD) [1,2]. In clear cell renal cell carcinoma (ccRCC), KL is an independent prognostic factor. Its down-regulation in ccRCC tissues is negatively associated with T stage, M stage, pathological stage, and histologic grade, indicating disease deterioration and a shortened overall survival period [3].

In conclusion, Kl is a crucial gene involved in multiple biological processes and disease conditions. Studies on its SNPs in T2DM, its role in the KL-FGF23-VD axis in LOAD, and as a prognostic factor in ccRCC, have enhanced our understanding of these diseases. These findings from model-based research contribute to a better understanding of disease mechanisms and may potentially lead to new treatment strategies.