C57BL/6JCya-Oatem1flox/Cya
Common Name:
Oat-flox
Product ID:
S-CKO-04061
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Oat-flox
Strain ID
CKOCMP-18242-Oat-B6J-VA
Gene Name
Product ID
S-CKO-04061
Gene Alias
rhg
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
7
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Oatem1flox/Cya mice (Catalog S-CKO-04061) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000084500
NCBI RefSeq
NM_016978
Target Region
Exon 3~5
Size of Effective Region
~4.3 kb
Detailed Document
Overview of Gene Research
Oat, with the scientific name Avena sativa, is an annual cereal. It is grown for forage, fodder, and grain. Seasonal flowering behavior (phenology) is a key factor in its success as a crop. As a vernalization-responsive long-day plant, it flowers in spring as days lengthen after winter [2].
Oats are considered the healthiest grain due to their high content of phytochemicals, dietary fibers, and protein. Oat protein and peptides obtained by enzymatic hydrolysis of proteins have various regulatory functions, such as antidiabetic, antioxidant, anti-hypoxic, antihypertensive, antithrombotic, antifatigue, immunomodulatory, and hypocholesterolemic properties. However, most studies are limited to in vitro conditions [1]. Oat consumption has also been associated with benefits like promoting immunomodulation, improving gut microbiota, and preventing diseases such as atherosclerosis, dermatitis, and some forms of cancer. Oat's beta-glucan, a major component of dietary fiber in oat grains, has proven cholesterol-lowering and antidiabetic effects [3]. Regarding lipid profile, oat consumption can reduce total cholesterol (TC), very-low-density lipoprotein (VLDL), and low-density lipoprotein cholesterol (LDL-C), and in some cases, with proper adjustment of factors like dose, duration, or combination with other elements, it can also improve triglyceride (TG) or high-density lipoprotein cholesterol (HDL-C) levels [4].
In conclusion, Oat is a valuable cereal with multiple health-beneficial properties. Although there is a lack of in vivo studies, especially those using gene knockout (KO) or conditional knockout (CKO) mouse models to precisely define its gene functions in disease-related pathways, existing research has shown its potential in promoting health and preventing various diseases. Future research should focus on conducting systematic animal and clinical trials to fully explore its functional food, nutraceutical, and therapeutic applications.
References:
1. Rafique, Hamad, Dong, Rui, Wang, Xiaolong, Zou, Liang, Hu, Xinzhong. 2022. Dietary-Nutraceutical Properties of Oat Protein and Peptides. In Frontiers in nutrition, 9, 950400. doi:10.3389/fnut.2022.950400. https://pubmed.ncbi.nlm.nih.gov/35866075/
2. Trevaskis, Ben, Harris, Felicity A J, Bovill, William D, Boden, Scott A, Hyles, Jessica. 2022. Advancing understanding of oat phenology for crop adaptation. In Frontiers in plant science, 13, 955623. doi:10.3389/fpls.2022.955623. https://pubmed.ncbi.nlm.nih.gov/36311119/
3. Paudel, Devendra, Dhungana, Bandana, Caffe, Melanie, Krishnan, Padmanaban. 2021. A Review of Health-Beneficial Properties of Oats. In Foods (Basel, Switzerland), 10, . doi:10.3390/foods10112591. https://pubmed.ncbi.nlm.nih.gov/34828872/
4. Amerizadeh, Atefeh, Ghaheh, Hooria Seyedhosseini, Vaseghi, Golnaz, Farajzadegan, Ziba, Asgary, Sedigheh. 2022. Effect of Oat (Avena sativa L.) Consumption on Lipid Profile With Focus on Triglycerides and High-density Lipoprotein Cholesterol (HDL-C): An Updated Systematic Review. In Current problems in cardiology, 48, 101153. doi:10.1016/j.cpcardiol.2022.101153. https://pubmed.ncbi.nlm.nih.gov/35192870/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen