C57BL/6JCya-Ccl20em1flox/Cya
Common Name
Ccl20-flox
Product ID
S-CKO-04953
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-20297-Ccl20-B6J-VA
When using this mouse strain in a publication, please cite “Ccl20-flox Mouse (Catalog S-CKO-04953) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Ccl20-flox
Strain ID
CKOCMP-20297-Ccl20-B6J-VA
Gene Name
Product ID
S-CKO-04953
Gene Alias
CKb4, LARC, ST38, MIP3A, MIP-3A, Scya20, MIP-3[a], exodus-1
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 1
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000113437
NCBI RefSeq
NM_016960
Target Region
Exon 2~3
Size of Effective Region
~0.9 kb
Overview of Gene Research
Ccl20, a chemokine, is mainly produced by epithelial cells. Its only known high-affinity ligand is for CCR6, driving the migration of CCR6+ cells in tissues. Ccl20 plays a crucial role in inflammatory responses and is involved in autoimmune diseases, cancer progression, and other pathological conditions [1,3].
In autoimmune diseases like inflammatory bowel disease (IBD), psoriasis (PS), rheumatoid arthritis (RA), and multiple sclerosis (MS), disruption of the CCR6-CCL20 interaction using antibodies or antagonists reduces the severity of the disease by preventing the migration of CCR6-expressing immune cells to the inflammation site [1]. In colorectal cancer, Fusobacterium nucleatum promotes cancer metastasis through the miR-1322/CCL20 axis and M2 polarization. CCL20 activated by F. nucleatum not only increases CRC metastasis but also participates in reprogramming the tumor microenvironment [2]. In preeclampsia, CCL20 might be a novel potential predictive and diagnostic biomarker as its levels are upregulated in the plasma of patients with this condition [4].
In conclusion, Ccl20 is essential in mediating cell migration in inflammatory and disease-related processes. Its role in autoimmune diseases and cancer progression is significant, as demonstrated through studies on disrupting its interaction with CCR6 or exploring its role in disease-associated axes. These findings provide potential therapeutic targets for treating autoimmune diseases and cancers [1,2,4].
References：
1. Meitei, Heikrujam Thoihen, Jadhav, Nandadeep, Lal, Girdhari. 2021. CCR6-CCL20 axis as a therapeutic target for autoimmune diseases. In Autoimmunity reviews, 20, 102846. doi:10.1016/j.autrev.2021.102846. https://pubmed.ncbi.nlm.nih.gov/33971346/
2. Xu, Chaochao, Fan, Lina, Lin, Yifeng, Si, Jianmin, Chen, Shujie. . Fusobacterium nucleatum promotes colorectal cancer metastasis through miR-1322/CCL20 axis and M2 polarization. In Gut microbes, 13, 1980347. doi:10.1080/19490976.2021.1980347. https://pubmed.ncbi.nlm.nih.gov/34632963/
3. Chen, Weilong, Qin, Yuanyuan, Liu, Suling. . CCL20 Signaling in the Tumor Microenvironment. In Advances in experimental medicine and biology, 1231, 53-65. doi:10.1007/978-3-030-36667-4_6. https://pubmed.ncbi.nlm.nih.gov/32060846/
4. Wang, Xiufang, Yip, Ka Cheuk, He, Andong, Zhang, Qiao, Li, Ruiman. 2022. Plasma Olink Proteomics Identifies CCL20 as a Novel Predictive and Diagnostic Inflammatory Marker for Preeclampsia. In Journal of proteome research, 21, 2998-3006. doi:10.1021/acs.jproteome.2c00544. https://pubmed.ncbi.nlm.nih.gov/36301636/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.