C57BL/6JCya-Sonem1flox/Cya
Common Name
Son-flox
Product ID
S-CKO-05171
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-20658-Son-B6J-VA
When using this mouse strain in a publication, please cite “Son-flox Mouse (Catalog S-CKO-05171) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Son-flox
Strain ID
CKOCMP-20658-Son-B6J-VA
Gene Name
Product ID
S-CKO-05171
Gene Alias
nrebp, mKIAA1019, 2900011L12Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 16
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000114037
NCBI RefSeq
NM_178880
Target Region
Exon 2
Size of Effective Region
~1.7 kb
Overview of Gene Research
Son of sevenless homologue 1 (SOS1) is a protein-coding gene. The SOS1 protein is ubiquitously expressed in cells and is crucial in the RAS signaling pathway. It interacts with RAS upon upstream stimuli, promoting guanine nucleotide exchange in RAS and activating downstream signaling pathways. Targeting SOS1 is emerging as a novel approach for treating RAS-driven cancers [1].
No information regarding KO/CKO mouse models or loss-of-function experiments was present in the provided abstracts.
In conclusion, SOS1 plays a vital role in the RAS signaling pathway, and its targeting shows promise in treating RAS-driven cancers. Further in vivo studies, such as those using KO/CKO mouse models, could potentially reveal more about its role in disease conditions and biological processes.
References：
1. Luo, Guangmei, Wang, Bingrui, Hou, Qiangqiang, Wu, Xiaoxing. 2023. Development of Son of Sevenless Homologue 1 (SOS1) Modulators To Treat Cancers by Regulating RAS Signaling. In Journal of medicinal chemistry, 66, 4324-4341. doi:10.1021/acs.jmedchem.2c01729. https://pubmed.ncbi.nlm.nih.gov/36987571/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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