C57BL/6JCya-Strapem1flox/Cya
Common Name:
Strap-flox
Product ID:
S-CKO-05406
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Strap-flox
Strain ID
CKOCMP-20901-Strap-B6J-VA
Gene Name
Product ID
S-CKO-05406
Gene Alias
Unrip
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
6
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Strapem1flox/Cya mice (Catalog S-CKO-05406) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000064910
NCBI RefSeq
NM_011499
Target Region
Exon 2
Size of Effective Region
~0.9 kb
Detailed Document
Overview of Gene Research
STRAP, short for Serine-threonine kinase receptor-associated protein, functions as a regulator in both TGF-β and p53 signaling pathways, participating in the regulation of cell proliferation and cell death in response to various stresses [1]. It is also implicated in tumorigenesis [2].
In mouse embryonic fibroblasts, loss of STRAP expression leads to reduced phospho-c-Jun and total c-Jun, along with decreased expression of cyclin D1 and a reduction in cell growth. STRAP regulates c-Jun stability by decreasing its ubiquitylation and proteosomal degradation [2].
In human neuroblastoma specimens, higher STRAP expression is correlated with high-risk disease, unfavorable histology, and decreased overall patient survival. Overexpression of STRAP in neuroblastoma cell lines promotes proliferation, growth, and a stem-like phenotype, and activates downstream FAK targets [3].
In conclusion, STRAP plays a crucial role in regulating cell-related processes such as proliferation and apoptosis through its involvement in key signaling pathways. Its dysregulation is associated with tumorigenesis, especially in neuroblastoma, highlighting its importance in understanding cancer-related biological mechanisms.
References：
1. Yu, Miao, Shi, Xiaoyan, Ren, Mengmeng, Wang, Wengong, Luo, Jianyuan. 2020. SIRT7 Deacetylates STRAP to Regulate p53 Activity and Stability. In International journal of molecular sciences, 21, . doi:10.3390/ijms21114122. https://pubmed.ncbi.nlm.nih.gov/32527012/
2. Reiner, Jennifer, Ye, Fei, Kashikar, Nilesh D, Datta, Pran K. 2011. STRAP regulates c-Jun ubiquitin-mediated proteolysis and cellular proliferation. In Biochemical and biophysical research communications, 407, 372-7. doi:10.1016/j.bbrc.2011.03.028. https://pubmed.ncbi.nlm.nih.gov/21397588/
3. Bownes, Laura V, Marayati, Raoud, Quinn, Colin H, Datta, Pran K, Beierle, Elizabeth A. 2022. Serine-Threonine Kinase Receptor Associate Protein (STRAP) confers an aggressive phenotype in neuroblastoma via regulation of Focal Adhesion Kinase (FAK). In Journal of pediatric surgery, 57, 1026-1032. doi:10.1016/j.jpedsurg.2022.01.064. https://pubmed.ncbi.nlm.nih.gov/35272839/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen