C57BL/6JCya-Ism2em1flox/Cya
Common Name:
Ism2-flox
Product ID:
S-CKO-06194
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Ism2-flox
Strain ID
CKOCMP-217738-Ism2-B6J-VA
Gene Name
Product ID
S-CKO-06194
Gene Alias
Gm264; Thsd3
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
12
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ism2em1flox/Cya mice (Catalog S-CKO-06194) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000125733
NCBI RefSeq
NM_001290302
Target Region
Exon 3
Size of Effective Region
~0.9 kb
Detailed Document
Overview of Gene Research
Isthmin 2 (ISM2) is a protein-coding gene. The Isthmin family, including ISM2, contains a TSR1 domain followed by an AMOP domain and is involved in diverse developmental and physiological processes [1].
A study found that ISM2 protein was decreased in patients with preeclampsia compared to the control group, suggesting its potential involvement in the pathogenesis of preeclampsia, and was overexpressed in choriocarcinoma, indicating a possible role in cancer angiogenesis [2]. Another study showed that low ISM2 expression was associated with a less advanced clinical stage and better survival outcomes in HPV-infected colorectal cancer, correlating with a strong tumor immune response [3]. Additionally, ISM2 was identified as one of the autoantibody-targeting genes in the discovery phase of developing a diagnostic tool for early esophageal squamous cell carcinoma [4].
In conclusion, ISM2 appears to play roles in angiogenesis-related processes such as in preeclampsia and choriocarcinoma, and is associated with the prognosis in HPV-infected colorectal cancer. Its involvement in autoantibody-related early esophageal squamous cell carcinoma diagnosis also shows its potential significance in disease diagnosis and pathophysiological processes.
References：
1. Shakhawat, Hosen Md, Hazrat, Zaman, Zhou, Zhongjun. 2022. Isthmin-A Multifaceted Protein Family. In Cells, 12, . doi:10.3390/cells12010017. https://pubmed.ncbi.nlm.nih.gov/36611811/
2. Martinez, Cynthia, González-Ramírez, Javier, Marín, María E, Mora, Rafael, Díaz-Molina, Raul. 2020. Isthmin 2 is decreased in preeclampsia and highly expressed in choriocarcinoma. In Heliyon, 6, e05096. doi:10.1016/j.heliyon.2020.e05096. https://pubmed.ncbi.nlm.nih.gov/33088937/
3. Zhou, Jianlong, Liu, Yongfeng, Zhang, Yucheng, Feng, Huolun, Li, Yong. 2024. Comprehensive analysis of a novel subtype of immune microenvironment-derived HPV-infected colorectal cancer. In Microbes and infection, 26, 105315. doi:10.1016/j.micinf.2024.105315. https://pubmed.ncbi.nlm.nih.gov/38417673/
4. Li, Tiandong, Sun, Guiying, Ye, Hua, Dai, Liping, Wang, Peng. 2024. ESCCPred: a machine learning model for diagnostic prediction of early esophageal squamous cell carcinoma using autoantibody profiles. In British journal of cancer, 131, 883-894. doi:10.1038/s41416-024-02781-w. https://pubmed.ncbi.nlm.nih.gov/38956246/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen