C57BL/6JCya-Cep170bem1flox/Cya
Common Name
Cep170b-flox
Product ID
S-CKO-06216
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-217882-Cep170b-B6J-VA
When using this mouse strain in a publication, please cite “Cep170b-flox Mouse (Catalog S-CKO-06216) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Cep170b-flox
Strain ID
CKOCMP-217882-Cep170b-B6J-VA
Gene Name
Product ID
S-CKO-06216
Gene Alias
Kiaa0284, mKIAA0284
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 12
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000101018
NCBI RefSeq
NM_001024602
Target Region
Exon 3~6
Size of Effective Region
~3.3 kb
Overview of Gene Research
Cep170b is a microtubule minus-end-binding protein. It is involved in controlling the spatial distribution of microtubule minus ends, which contributes to the establishment of a polarized microtubule network and cell polarity. It depends on liprin-α1 for cortical targeting and liprin-α1-bound PP2A phosphatase for microtubule localization [1].
Cep170b has been identified in various genetic analyses. In transcriptomic studies related to epilepsy and glioma, it was among the genes screened in weight gene co-expression network (WGCNA) analysis, suggesting its potential role in these diseases [2]. In temporal lobe epilepsy research, Cep170b was found to interact with miR-484 in a miRNA-mRNA network, and bioinformatics analysis indicated its involvement in cellular-related biological functions and the neurotransmitter synapse pathway [3].
In conclusion, Cep170b is crucial for regulating the microtubule minus-end distribution, which is essential for cell polarity. Its identification in studies related to epilepsy and glioma, as well as in miRNA-mRNA network research in temporal lobe epilepsy, shows its potential significance in these disease areas. The research on Cep170b provides insights into the underlying biological mechanisms and may offer new directions for disease-related studies.
References：
1. Guan, Cuirong, Hua, Shasha, Jiang, Kai. 2023. The CEP170B-KIF2A complex destabilizes microtubule minus ends to generate polarized microtubule network. In The EMBO journal, 42, e112953. doi:10.15252/embj.2022112953. https://pubmed.ncbi.nlm.nih.gov/37014312/
2. Zhao, Kai, Bai, Xuexue, Wang, Xiao, Li, Wei, Wang, Shiyong. 2023. Insight on the hub gene associated signatures and potential therapeutic agents in epilepsy and glioma. In Brain research bulletin, 199, 110666. doi:10.1016/j.brainresbull.2023.110666. https://pubmed.ncbi.nlm.nih.gov/37192718/
3. Li, Xing, Han, Yunli, Li, Dejun, Chen, Xiaolan, Qin, Yuanhan. 2021. Identification and Validation of a Dysregulated miRNA-Associated mRNA Network in Temporal Lobe Epilepsy. In BioMed research international, 2021, 4118216. doi:10.1155/2021/4118216. https://pubmed.ncbi.nlm.nih.gov/34722763/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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