Cep170b is a microtubule minus-end-binding protein. It is involved in controlling the spatial distribution of microtubule minus ends, which contributes to the establishment of a polarized microtubule network and cell polarity. It depends on liprin-α1 for cortical targeting and liprin-α1-bound PP2A phosphatase for microtubule localization [1].

Cep170b has been identified in various genetic analyses. In transcriptomic studies related to epilepsy and glioma, it was among the genes screened in weight gene co-expression network (WGCNA) analysis, suggesting its potential role in these diseases [2]. In temporal lobe epilepsy research, Cep170b was found to interact with miR-484 in a miRNA-mRNA network, and bioinformatics analysis indicated its involvement in cellular-related biological functions and the neurotransmitter synapse pathway [3].

In conclusion, Cep170b is crucial for regulating the microtubule minus-end distribution, which is essential for cell polarity. Its identification in studies related to epilepsy and glioma, as well as in miRNA-mRNA network research in temporal lobe epilepsy, shows its potential significance in these disease areas. The research on Cep170b provides insights into the underlying biological mechanisms and may offer new directions for disease-related studies.