C57BL/6JCya-Vimem1flox/Cya
Common Name:
Vim-flox
Product ID:
S-CKO-06613
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Vim-flox
Strain ID
CKOCMP-22352-Vim-B6J-VA
Gene Name
Product ID
S-CKO-06613
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
2
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Vimem1flox/Cya mice (Catalog S-CKO-06613) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000028062
NCBI RefSeq
NM_011701
Target Region
Exon 3~7
Size of Effective Region
~4.0 kb
Detailed Document
Overview of Gene Research
Vim, short for ventralis intermedius, is a nucleus of the thalamus. It serves as a crucial surgical target for tremor treatment [1,2]. The Vim neurons respond to passive joint movements and are synchronous with peripheral tremor, and there is a well-defined limit between the motor and sensory thalamus where Vim is located [1,2].
The location of the Vim nucleus is difficult to identify with conventional imaging methods. Surgical procedures often rely on indirect calculations correlated with clinical and intraoperative neurophysiological findings. Stereotactic coordinates for the Vim nucleus are typically based on references to the mid-commissural line and third ventricle, but these vary between patients [1,2]. New techniques like tractography for direct location are being explored, though it has limitations and requires standardization to precisely locate the Vim nucleus for tremor treatment [1,2]. The Vim line technique, created using a mathematical model, can also be used to identify the Vim location, and its effectiveness was demonstrated by decreased Unified Parkinson's Disease Rating Scale (UPDRS) scores in patients after Vim thalamotomy [3,4].
Deep brain stimulation (DBS) of the Vim is an effective treatment for essential tremor, and studies on Vim-DBS programming sessions show its continuous efficacy in tremor suppression over time [5]. Also, Vim-PSA double-target DBS surgery has specific technical issues related to target location, burr hole drilling, pneumocephalus reduction, and intraoperative electrophysiological verification [6].
In conclusion, Vim is of great significance in tremor treatment. Research on its location-determination methods and treatment-related techniques, such as those involving DBS, helps in better understanding the role of Vim in tremor-related biological processes. These studies provide a basis for more effective surgical treatments for tremor patients.
References:
1. Parras, O, Domínguez, P, Tomás-Biosca, A, Guridi, J. 2020. The role of tractography in the localization of the Vim nucleus of the thalamus and the dentato-rubro-thalamic tract for the treatment of tremor. In Neurologia, 37, 691-699. doi:10.1016/j.nrl.2019.09.006. https://pubmed.ncbi.nlm.nih.gov/31917004/
2. Parras, O, Domínguez, P, Tomás-Biosca, A, Guridi, J. 2021. The role of tractography in the localisation of the Vim nucleus of the thalamus and the dentatorubrothalamic tract for the treatment of tremor. In Neurologia, 37, 691-699. doi:10.1016/j.nrleng.2019.09.008. https://pubmed.ncbi.nlm.nih.gov/34563477/
3. Fahmi, Achmad, Subianto, Heri, Nugraha, Priya, Taira, Takaomi, Bajamal, Abdul Hafid. . VIM Line Technique for Determining the Ventral Intermediate Location. In Turkish neurosurgery, 31, 601-606. doi:10.5137/1019-5149.JTN.31961-20.2. https://pubmed.ncbi.nlm.nih.gov/33978218/
4. Fahmi, Achmad, Subianto, Heri, Nugraha, Priya, Taira, Takaomi, Bajamal, Abdul Hafid. 2020. Vim line technique thalamotomy for Parkinson tremor: Case series. In International journal of surgery case reports, 77, 573-575. doi:10.1016/j.ijscr.2020.11.096. https://pubmed.ncbi.nlm.nih.gov/33395848/
5. Reitz, Sarah C, Luger, Sebastian, Lapa, Sriramya, Baudrexel, Simon, Quick-Weller, Johanna. 2020. Comparing Programming Sessions of Vim-DBS. In Frontiers in neurology, 11, 987. doi:10.3389/fneur.2020.00987. https://pubmed.ncbi.nlm.nih.gov/33013651/
6. Hou, Xusheng, Mo, Yixiang, Zhu, Zhiyuan, Li, Mengqian, Zhang, Shizhong. 2023. Technical Issues of Vim-PSA Double-Target DBS for Essential Tremor. In Brain sciences, 13, . doi:10.3390/brainsci13040566. https://pubmed.ncbi.nlm.nih.gov/37190531/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen