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C57BL/6JCya-Gm94em1flox/Cya
Common Name:
Gm94-flox
Product ID:
S-CKO-06831
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Gm94-flox
Strain ID
CKOCMP-225443-Gm94-B6J-VA
Gene Name
Gm94
Product ID
S-CKO-06831
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
225443
Modification
Conditional knockout
Chromosome
18
Phenotype
MGI:2684940
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Gm94em1flox/Cya mice (Catalog S-CKO-06831) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000096570
NCBI RefSeq
NM_001033280
Target Region
Exon 2
Size of Effective Region
~1.4 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Gm94 is encoded by the mouse C5orf46 homologous gene. It is involved in the innate immune response, specifically exhibiting antimicrobial activity, which is crucial for the body's first line of defense against microbes [1].

Gm94 closely resembles AP-64, an antimicrobial peptide encoded by human C5orf46, in its antibacterial properties. AP-64 shows significant antibacterial activity against Gram-negative bacteria like Escherichia coli and Vibrio cholerae, and is also efficient in combating Escherichia coli O157:H7 infections in a mouse model. Since Gm94 has similar antibacterial properties, it can be inferred that it may play a similar role in the innate immune response in mice [1].

In conclusion, Gm94, through its antibacterial properties similar to AP-64, plays an important role in the innate immune response in mice. The study of Gm94 using mouse models helps to understand the innate immune mechanism against Gram-negative bacteria, providing insights into potential therapeutic strategies for related infectious diseases [1].

References:
1. Zhong, Kunhong, Wang, Yuelong, Wang, Zeng, Yang, Hui, Tong, Aiping. 2021. AP-64, Encoded by C5orf46, Exhibits Antimicrobial Activity against Gram-Negative Bacteria. In Biomolecules, 11, . doi:10.3390/biom11040485. https://pubmed.ncbi.nlm.nih.gov/33804835/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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