C57BL/6JCya-Kizem1flox/Cya
Common Name:
Kiz-flox
Product ID:
S-CKO-07185
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Kiz-flox
Strain ID
CKOCMP-228730-Kiz-B6J-VA
Gene Name
Product ID
S-CKO-07185
Gene Alias
Gm114; Ncrna00153; Plk1s1
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
2
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Kizem1flox/Cya mice (Catalog S-CKO-07185) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000099278
NCBI RefSeq
NM_001033298.4
Target Region
Exon 5~6
Size of Effective Region
~3.3 kb
Detailed Document
Overview of Gene Research
Kiz, also known as GM114, is a negative regulator that balances the NF-κB signaling pathway. NF-κB signaling is crucial for the inflammatory response, and tight control of this pathway is necessary to prevent chronic inflammatory and autoimmune diseases. Kiz binds to TRAF6/2 by targeting their TRAF domains, antagonizing the association of TRAF6 with IRAK1 or TRAF2 with TRADD, thus reducing IL-1β/LPS/TNFα-induced NF-κB activation [1].
In a dextran sulfate sodium-treated mouse model, Gm114 deficiency led to a stronger inflammatory response, more severe acute colitis, and a lower survival rate compared to control mice. This indicates that Kiz plays a significant role in limiting excessive inflammatory response in vivo [1].
In conclusion, Kiz is essential for maintaining the balance of the NF-κB signaling pathway. Through gene knockout studies in mouse models, it has been revealed that Kiz is crucial in controlling the inflammatory response, suggesting its potential as a target for treating diseases related to excessive inflammation such as acute colitis.
References：
1. Sun, Jiawei, Yang, Qili, Liu, Enping, Chen, Dahua, Sun, Qinmiao. 2022. KIZ/GM114 Balances the NF-ĸB Signaling by Antagonizing the Association of TRAF2/6 With Their Upstream Adaptors. In Frontiers in cell and developmental biology, 10, 877039. doi:10.3389/fcell.2022.877039. https://pubmed.ncbi.nlm.nih.gov/35433693/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen