C57BL/6JCya-Prss50em1flox/Cya
Common Name
Prss50-flox
Product ID
S-CKO-07862
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-235631-Prss50-B6J-VA
When using this mouse strain in a publication, please cite “Prss50-flox Mouse (Catalog S-CKO-07862) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Prss50-flox
Strain ID
CKOCMP-235631-Prss50-B6J-VA
Gene Name
Product ID
S-CKO-07862
Gene Alias
Tsp50, 79H19C
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 9
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000051097
NCBI RefSeq
NM_146227
Target Region
Exon 2
Size of Effective Region
~0.7 kb
Overview of Gene Research
Prss50, also known as serine protease 50 or TSP50, is a gene highly expressed in spermatocytes. It plays a crucial role in testicular development and spermatogenesis, with its function associated with the MKP3/ERK signaling pathway [1].
Prss50 -/- mouse models have provided valuable insights into its functions. In these knockout mice, there are abnormal spermatid nuclear compression, reduced male fertility, dysplastic seminiferous tubules, decreased sex hormones, meiotic progression defects, and increased apoptosis of spermatogenic cells [1]. Additionally, Prss50 -null mice show impaired sperm tail formation and function, along with multiple morphological abnormalities of the sperm flagella, such as an increase in acephalic sperm, sperm with multiple heads and tails [2].
In conclusion, Prss50 is essential for testicular development, spermatogenesis, and proper sperm tail formation and function. The Prss50 -/- mouse models have significantly contributed to understanding its role in male fertility-related processes, providing insights into the complex mechanisms of sperm development and the importance of testis proteases in fertility [1,2].
References：
1. Niu, Chun-Xue, Li, Jia-Wei, Li, Xiao-Li, Wang, Guan-Nan, Bao, Yong-Li. . PRSS50-mediated inhibition of MKP3/ERK signaling is crucial for meiotic progression and sperm quality. In Zoological research, 45, 1037-1047. doi:10.24272/j.issn.2095-8137.2023.388. https://pubmed.ncbi.nlm.nih.gov/39147718/
2. Scovell, Jason M, Bournat, Juan C, Szafran, Adam T, Seth, Abhishek, Jorgez, Carolina J. 2021. PRSS50 is a testis protease responsible for proper sperm tail formation and function. In Development (Cambridge, England), 148, . doi:10.1242/dev.197558. https://pubmed.ncbi.nlm.nih.gov/33913480/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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