C57BL/6JCya-Mmgt1em1flox/Cya
Common Name
Mmgt1-flox
Product ID
S-CKO-07890
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-236792-Mmgt1-B6J-VA
When using this mouse strain in a publication, please cite “Mmgt1-flox Mouse (Catalog S-CKO-07890) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Mmgt1-flox
Strain ID
CKOCMP-236792-Mmgt1-B6J-VA
Gene Name
Product ID
S-CKO-07890
Gene Alias
Emc5, Tmem32, Mir5116, mir-5116, 9630048L06Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr X
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000059899
NCBI RefSeq
NM_146234
Target Region
Exon 2
Size of Effective Region
~1.1 kb
Overview of Gene Research
Mmgt1, short for membrane magnesium transporter 1, is a key component in magnesium (Mg²⁺) transport. It belongs to a novel family of membrane magnesium transporters and resides in the Golgi complex and post-Golgi vesicles. MMgT1 mediates Mg²⁺ transport, which is crucial for various cellular functions, and its expression can be regulated by extracellular Mg²⁺ levels [2].
In Mycobacterium tuberculosis (Mtb) infection, Mtb-infected MMGT1-deficient macrophages show a switch to persistence, upregulation of lipid metabolism genes, and lipid droplet accumulation. This indicates that MMGT1 is involved in the process of Mtb persistence, potentially through its influence on lipid metabolism [1].
In summary, MMGT1 is essential for Mg²⁺ transport in cells. The gene knockout model of MMGT1 in macrophages has revealed its role in the Mtb-host interaction, specifically in the induction of Mtb persistence. Understanding MMGT1 can provide insights into the mechanisms underlying Mtb infection and potentially contribute to the development of new treatment strategies for tuberculosis.
References：
1. Kalam, Haroon, Chou, Chih-Hung, Kadoki, Motohiko, Hung, Deborah T, Xavier, Ramnik J. 2023. Identification of host regulators of Mycobacterium tuberculosis phenotypes uncovers a role for the MMGT1-GPR156 lipid droplet axis in persistence. In Cell host & microbe, 31, 978-992.e5. doi:10.1016/j.chom.2023.05.009. https://pubmed.ncbi.nlm.nih.gov/37269834/
2. Goytain, Angela, Quamme, Gary A. 2007. Identification and characterization of a novel family of membrane magnesium transporters, MMgT1 and MMgT2. In American journal of physiology. Cell physiology, 294, C495-502. doi:. https://pubmed.ncbi.nlm.nih.gov/18057121/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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