C57BL/6JCya-Lrit2em1flox/Cya
Common Name
Lrit2-flox
Product ID
S-CKO-08082
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-239038-Lrit2-B6J-VA
When using this mouse strain in a publication, please cite “Lrit2-flox Mouse (Catalog S-CKO-08082) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Lrit2-flox
Strain ID
CKOCMP-239038-Lrit2-B6J-VA
Gene Name
Product ID
S-CKO-08082
Gene Alias
Lrrc22, A930010E21Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 14
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000057176
NCBI RefSeq
NM_173418
Target Region
Exon 1~2
Size of Effective Region
~2.3 kb
Overview of Gene Research
Lrit2 is a gene that has been newly discovered to be involved in visual functions. However, no common aliases, associated pathways are mentioned in the given reference. Its discovery emphasizes the importance of genetic models in understanding gene functions in mammalian systems [1].
Through an integrated transcriptome-phenome analysis in mice, >50 genes were predicted to be involved in mouse visual functions, among which Lrit2 was one. Gene-specific morpholinos were introduced into zebrafish to target the orthologs of selected genes. Quantitative assessments of developing eye phenotypes in zebrafish confirmed the predicted eye-related functions of Lrit2, along with 12 other genes out of the 15 examined [1].
In conclusion, Lrit2 is a gene with eye-related functions as revealed through model-based research. The study using zebrafish as a model, based on the integrated analysis in mice, contributes to understanding the functional landscape of genes related to visual functions, providing insights into potential mechanisms underlying eye-related biological processes [1].
References：
1. Chiang, Chia-Yin, Ching, Yung-Hao, Chang, Ting-Yan, Lin, Ming-Der, Liao, Ben-Yang. 2019. Novel eye genes systematically discovered through an integrated analysis of mouse transcriptomes and phenome. In Computational and structural biotechnology journal, 18, 73-82. doi:10.1016/j.csbj.2019.12.009. https://pubmed.ncbi.nlm.nih.gov/31934309/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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