C57BL/6JCya-Gm4952em1flox/Cya
Common Name:
Gm4952-flox
Product ID:
S-CKO-08266
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Gm4952-flox
Strain ID
CKOCMP-240549-Gm4952-B6J-VA
Gene Name
Product ID
S-CKO-08266
Gene Alias
EG240549
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
19
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Gm4952em1flox/Cya mice (Catalog S-CKO-08266) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000092931
NCBI RefSeq
NM_001013762
Target Region
Exon 4
Size of Effective Region
~0.6 kb
Detailed Document
Overview of Gene Research
Gm4952 is a gene whose specific functions, common aliases, and associated pathways have not been widely established in general biological knowledge. However, genetic models can be crucial for understanding its functions in vivo.
In a study on the effects of pre-conceptional glyphosate (GLY) exposure in mice, it was found that in dams at gestation day 14 (GD14), GLY exposure increased the hepatic protein abundance of Gm4952 by approximately 4-fold (p < 0.05) [1].
Overall, while the exact biological functions of Gm4952 remain to be fully elucidated, the model-based research using mice exposed to GLY suggests that Gm4952 may be involved in the hepatic response to pre-conceptional glyphosate exposure. This provides a starting point for further functional studies of Gm4952 in relation to environmental chemical-induced impacts on liver function.
References：
1. Novbatova, Gulnara, Timme, Kelsey, Severin, Andrew, Sayadi, Maryam, Keating, Aileen F. . Pre-Conceptional Exposure to Glyphosate Affects the Maternal Hepatic and Ovarian Proteome. In Toxicological sciences : an official journal of the Society of Toxicology, 190, 204-214. doi:10.1093/toxsci/kfac098. https://pubmed.ncbi.nlm.nih.gov/36173347/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen