C57BL/6JCya-Nlrp4aem1flox/Cya
Common Name
Nlrp4a-flox
Product ID
S-CKO-08551
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-243880-Nlrp4a-B6J-VA
When using this mouse strain in a publication, please cite “Nlrp4a-flox Mouse (Catalog S-CKO-08551) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Nlrp4a-flox
Strain ID
CKOCMP-243880-Nlrp4a-B6J-VA
Gene Name
Product ID
S-CKO-08551
Gene Alias
E330021B02, E330028A19Rik, NALP4, Nalp-eta, Nalp-ita, Nalp4a
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 7
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000068767
NCBI RefSeq
NM_172896
Target Region
Exon 4
Size of Effective Region
~3.7 kb
Overview of Gene Research
Nlrp4a, a member of the Nlrp gene family, which contains 20 members in mice and plays a crucial role in the innate immune and reproductive systems. During evolution, seven Nlrp4 gene copies (Nlrp4a-Nlrp4g) emerged, with some showing specific or preferential ovarian expression patterns. However, the reference mainly focuses on Nlrp4g, and no direct information about Nlrp4a is provided from this single reference [1].
Since no information regarding Nlrp4a from KO/CKO mouse models or other loss-of-function experiments is available in the given reference, this paragraph is omitted.
In conclusion, as the reference doesn't provide direct details about Nlrp4a, more research, especially using gene knockout (KO) or conditional knockout (CKO) mouse models, is needed to understand its essential biological functions, its role in specific biological processes or disease conditions within the context of the innate immune and reproductive systems where the Nlrp gene family is important.
References：
1. Peng, Hui, Lin, Xiujiao, Li, Wenhao, Zhang, Wenchang. 2014. Expression and localization of Nlrp4g in mouse preimplantation embryo. In Zygote (Cambridge, England), 23, 846-51. doi:10.1017/S0967199414000525. https://pubmed.ncbi.nlm.nih.gov/25384339/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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