C57BL/6JCya-Lhfpl3em1flox/Cya
Common Name:
Lhfpl3-flox
Product ID:
S-CKO-09823
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Lhfpl3-flox
Strain ID
CKOCMP-269629-Lhfpl3-B6J-VA
Gene Name
Product ID
S-CKO-09823
Gene Alias
A930031L14Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
5
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Lhfpl3em1flox/Cya mice (Catalog S-CKO-09823) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000197992
NCBI RefSeq
NM_001081231
Target Region
Exon 1
Size of Effective Region
~3.0 kb
Detailed Document
Overview of Gene Research
Lhfpl3, lipoma HMGIC fusion partner-like 3, has been involved in multiple biological processes. Its abnormal regulation is associated with various diseases, suggesting its significance in maintaining normal cellular functions [1,2].
In a 24-year-old female with dysembryoplastic neuroepithelial tumor, a novel in-frame fusion between LHFPL3 and NTRK2 was verified. This oncogenic gene rearrangement likely involves aberrant dimerization and constitutive activation of RTK signaling pathways [1].
In glioma cells, miR-218-5p was found to target LHFPL3. Transfection of miR-218-5p reduced cell activity, proliferation, invasive ability and inhibited epithelial-mesenchymal transitions, indicating LHFPL3's role in glioma cell invasiveness [2].
In conclusion, Lhfpl3 is implicated in the pathogenesis of certain nervous system tumors like dysembryoplastic neuroepithelial tumor and glioma. The discovery of its fusion with NTRK2 and regulation by miR-218-5p provides insights into the molecular mechanisms underlying these diseases, which may potentially lead to new therapeutic strategies.
References：
1. Chen, Yanming, Zhu, Qing, Wang, Ye, Xiao, Sheng, Lan, Qing. 2022. Case Report: A novel LHFPL3::NTRK2 fusion in dysembryoplastic neuroepithelial tumor. In Frontiers in oncology, 12, 1064817. doi:10.3389/fonc.2022.1064817. https://pubmed.ncbi.nlm.nih.gov/36531047/
2. Li, Zhixiao, Qian, Rongjun, Zhang, Jiadong, Shi, Xiwen. 2019. MiR-218-5p targets LHFPL3 to regulate proliferation, migration, and epithelial-mesenchymal transitions of human glioma cells. In Bioscience reports, 39, . doi:10.1042/BSR20180879. https://pubmed.ncbi.nlm.nih.gov/30314994/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen