C57BL/6JCya-D6Wsu163eem1flox/Cya
Common Name
D6Wsu163e-flox
Product ID
S-CKO-10122
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-28040-D6Wsu163e-B6J-VA
When using this mouse strain in a publication, please cite “D6Wsu163e-flox Mouse (Catalog S-CKO-10122) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
D6Wsu163e-flox
Strain ID
CKOCMP-28040-D6Wsu163e-B6J-VA
Gene Name
Product ID
S-CKO-10122
Gene Alias
C12orf4
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 6
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000032497
NCBI RefSeq
NM_138594
Target Region
Exon 4
Size of Effective Region
~1.5 kb
Overview of Gene Research
D6Wsu163e is a murine gene. However, from the given content, no information is provided regarding its function, associated pathways, or overall biological importance. Its study in genetic models could potentially offer insights into these aspects.
The research aimed to find pathogenic and likely pathogenic (PLP) variants in human-mouse ortholog HI genes in African individuals with non-syndromic hearing impairment. Among 34 novel human-mouse orthologs HI genes studied, D6Wsu163e was one of the 4 murine genes that had no human orthologs [1].
In conclusion, although D6Wsu163e has no human ortholog as per this study, understanding its function in mouse models could potentially contribute to knowledge of hearing-related biology, given the similarity between human and murine hearing systems. This could offer insights into the physiology of hearing and potentially related disease mechanisms.
References：
1. Oluwole, Oluwafemi G, Esoh, Kevin K, Wonkam-Tingang, Edmond, Chimusa, Emile R, Wonkam, Ambroise. 2020. Whole exome sequencing identifies rare coding variants in novel human-mouse ortholog genes in African individuals diagnosed with non-syndromic hearing impairment. In Experimental biology and medicine (Maywood, N.J.), 246, 197-206. doi:10.1177/1535370220960388. https://pubmed.ncbi.nlm.nih.gov/32996353/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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