C57BL/6JCya-Mroh7em1flox/Cya
Common Name:
Mroh7-flox
Product ID:
S-CKO-10955
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Mroh7-flox
Strain ID
CKOCMP-381538-Mroh7-B6J-VA
Gene Name
Product ID
S-CKO-10955
Gene Alias
Gm1027; Heatr8
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
4
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Mroh7em1flox/Cya mice (Catalog S-CKO-10955) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000106770
NCBI RefSeq
NM_001126487
Target Region
Exon 4
Size of Effective Region
~1.0 kb
Detailed Document
Overview of Gene Research
Mroh7 is a gene that has been studied in relation to various biological contexts. While its exact function and associated pathways are not comprehensively detailed from the provided references, it has been identified in studies exploring different physiological and disease-related processes [1,2].
In one study, individual disruption of Mroh7 via the Nuclease technology system in male mice did not affect male fertility, suggesting that it may not be an essential gene for male fertility when acting alone [1]. Another study found that in a rat model of ventilator-induced lung injury (VILI), Mroh7 was among 13 genes whose expression levels recovered to control levels after ginsenoside pretreatment, indicating a potential role in the response to VILI [2].
In conclusion, through gene knockout studies in mice, Mroh7 has been shown not to be individually essential for male fertility. In the context of VILI, Mroh7's expression changes upon ginsenoside treatment imply its possible involvement in the inflammatory and oxidative stress response related to this lung injury. These model-based research findings contribute to understanding the gene's role in specific biological processes and disease conditions.
References:
1. Suzuki, Akira, Yabuta, Norikazu, Shimada, Keisuke, Matzuk, Martin M, Ikawa, Masahito. 2024. Individual disruption of 12 testis-enriched genes via the Nuclease technology system does not affect the fertility of male mice. In Journal of reproductive immunology, 163, 104252. doi:10.1016/j.jri.2024.104252. https://pubmed.ncbi.nlm.nih.gov/38697008/
2. Cho, Woo Hyun, Kim, Yun Hak, Heo, Hye Jin, Kim, Kwang Ho, Yeo, Hye Ju. 2020. Ginsenoside ameliorated ventilator-induced lung injury in rats. In Journal of intensive care, 8, 89. doi:10.1186/s40560-020-00509-5. https://pubmed.ncbi.nlm.nih.gov/33292607/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen