C57BL/6JCya-Nicol1em1flox/Cya
Common Name:
Nicol1-flox
Product ID:
S-CKO-10967
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Nicol1-flox
Strain ID
CKOCMP-381633-Nicol1-B6J-VA
Gene Name
Product ID
S-CKO-10967
Gene Alias
Gm1673
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
5
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Nicol1em1flox/Cya mice (Catalog S-CKO-10967) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000094869
NCBI RefSeq
NM_001033458
Target Region
Exon 2~3
Size of Effective Region
~0.7 kb
Detailed Document
Overview of Gene Research
Nicol1 is identified as a gatekeeper of the stem cell state in trophoblast stem cells. Its function likely plays a crucial role in placental formation, which involves the expansion of trophoblast stem and progenitor cells and subsequent lineage specification. Understanding Nicol1 could potentially provide insights into the molecular mechanisms underlying placental development [1].
The study using single-cell RNA sequencing of mouse trophoblast stem cells during early differentiation identified Nicol1. Although the abstract doesn't specifically mention gene knockout (KO) or conditional knockout (CKO) mouse models for Nicol1, it emphasizes its role as a stem cell state gatekeeper, suggesting that disruption of Nicol1 in such models might lead to abnormal placental development [1].
In conclusion, Nicol1 is important as a gatekeeper of the stem cell state in trophoblast stem cells, which is essential for placental formation. While direct evidence from KO/CKO mouse models is lacking in the provided abstract, its identification paves the way for future in vivo studies using these models to understand its role in placental-related diseases [1].
References：
1. Angelova, Dafina M, Tsolova, Aleksandra, Prater, Malwina, Hemberger, Myriam, Charnock-Jones, D Stephen. 2025. Single-cell RNA sequencing identifies CXADR as a fate determinant of the placental exchange surface. In Nature communications, 16, 142. doi:10.1038/s41467-024-55597-w. https://pubmed.ncbi.nlm.nih.gov/39747179/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen