C57BL/6JCya-Nicol1em1flox/Cya
Common Name
Nicol1-flox
Product ID
S-CKO-10967
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-381633-Nicol1-B6J-VA
When using this mouse strain in a publication, please cite “Nicol1-flox Mouse (Catalog S-CKO-10967) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Nicol1-flox
Strain ID
CKOCMP-381633-Nicol1-B6J-VA
Gene Name
Product ID
S-CKO-10967
Gene Alias
NICOL, Gm1673
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 5
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000094869
NCBI RefSeq
NM_001033458
Target Region
Exon 2~3
Size of Effective Region
~0.7 kb
Overview of Gene Research
Nicol1 is identified as a gatekeeper of the stem cell state in trophoblast stem cells. Its function likely plays a crucial role in placental formation, which involves the expansion of trophoblast stem and progenitor cells and subsequent lineage specification. Understanding Nicol1 could potentially provide insights into the molecular mechanisms underlying placental development [1].
The study using single-cell RNA sequencing of mouse trophoblast stem cells during early differentiation identified Nicol1. Although the abstract doesn't specifically mention gene knockout (KO) or conditional knockout (CKO) mouse models for Nicol1, it emphasizes its role as a stem cell state gatekeeper, suggesting that disruption of Nicol1 in such models might lead to abnormal placental development [1].
In conclusion, Nicol1 is important as a gatekeeper of the stem cell state in trophoblast stem cells, which is essential for placental formation. While direct evidence from KO/CKO mouse models is lacking in the provided abstract, its identification paves the way for future in vivo studies using these models to understand its role in placental-related diseases [1].
References：
1. Angelova, Dafina M, Tsolova, Aleksandra, Prater, Malwina, Hemberger, Myriam, Charnock-Jones, D Stephen. 2025. Single-cell RNA sequencing identifies CXADR as a fate determinant of the placental exchange surface. In Nature communications, 16, 142. doi:10.1038/s41467-024-55597-w. https://pubmed.ncbi.nlm.nih.gov/39747179/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.